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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.68 (2022) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/1935
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| Title: | Successful management of pelvic recurrence of MSI-High endometrial cancer by total pelvic exenteration followed by administration of pembrolizumab:A case report |
| Authors: | Kojima, Manabu
Soeda, Shu
Okabe, Chikako
Sato, Tetsu
Kamo, Norihito
Ueda, Makiko
Endo, Yuta
Nomura, Shinji
Tokuda, Emi
Furukawa, Shigenori
Kataoka, Masao
Fujita, Shotaro
Saji, Shigehira
Watanabe, Takafumi
Fujimori, Keiya |
| Affiliation: | 産科婦人科学講座
腫瘍内科学講座
泌尿器科学講座
消化管外科学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 68 |
| Issue: | 3 |
| Start page: | 191 |
| End page: | 195 |
| Issue Date: | 2022 |
| Abstract: | Surgery can be curative treatment for pelvic locoregional recurrence of endometrial cancer; however, a cure is contingent on complete resection. Here, we report the case of a patient in whom recurrent endometrial tumor remained in the pelvis after resection; long-term control was achieved with postoperative administration of pembrolizumab.The patient had recurrent endometrial cancer of stage IA and was treated with chemotherapy and radiation, but tumor persisted in the pelvic cavity. We therefore attempted total pelvic exenteration, but the tumor was adherent to the pelvic wall and complete resection could not be achieved. However, postoperative administration of pembrolizumab controlled the residual tumor for more than two years without regrowth. We believe that since the resected tumor was MSI-High, the residual tumor responded well to pembrolizumab. It is not known whether cytoreductive surgery contributes to a long-term response to pembrolizumab, but at least in our patient, pembrolizumab appeared to be a very effective drug therapy for MSI-High endometrial cancer that was refractory to chemotherapy and radiotherapy. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/1935 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/1935/1/FksmJMedSci_68_p191.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2022-10 |
| PubMed ID: | 36351631 |
| Related Page: | https://doi.org/10.5387/fms.2022-10 |
| Rights: | © 2022 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| Rights: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| Appears in Collections: | Vol.68 (2022)
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