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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.68 (2022) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/1935
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| タイトル: | Successful management of pelvic recurrence of MSI-High endometrial cancer by total pelvic exenteration followed by administration of pembrolizumab:A case report |
| 著者: | Kojima, Manabu
Soeda, Shu
Okabe, Chikako
Sato, Tetsu
Kamo, Norihito
Ueda, Makiko
Endo, Yuta
Nomura, Shinji
Tokuda, Emi
Furukawa, Shigenori
Kataoka, Masao
Fujita, Shotaro
Saji, Shigehira
Watanabe, Takafumi
Fujimori, Keiya |
| 学内所属: | 産科婦人科学講座
腫瘍内科学講座
泌尿器科学講座
消化管外科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 68 |
| 号: | 3 |
| 開始ページ: | 191 |
| 終了ページ: | 195 |
| 発行日: | 2022年 |
| 抄録: | Surgery can be curative treatment for pelvic locoregional recurrence of endometrial cancer; however, a cure is contingent on complete resection. Here, we report the case of a patient in whom recurrent endometrial tumor remained in the pelvis after resection; long-term control was achieved with postoperative administration of pembrolizumab.The patient had recurrent endometrial cancer of stage IA and was treated with chemotherapy and radiation, but tumor persisted in the pelvic cavity. We therefore attempted total pelvic exenteration, but the tumor was adherent to the pelvic wall and complete resection could not be achieved. However, postoperative administration of pembrolizumab controlled the residual tumor for more than two years without regrowth. We believe that since the resected tumor was MSI-High, the residual tumor responded well to pembrolizumab. It is not known whether cytoreductive surgery contributes to a long-term response to pembrolizumab, but at least in our patient, pembrolizumab appeared to be a very effective drug therapy for MSI-High endometrial cancer that was refractory to chemotherapy and radiotherapy. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/1935 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/1935/1/FksmJMedSci_68_p191.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2022-10 |
| PubMed番号: | 36351631 |
| 関連ページ: | https://doi.org/10.5387/fms.2022-10 |
| 権利情報: | © 2022 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| 権利情報: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| 出現コレクション: | Vol.68 (2022)
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