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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.59 (2013) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/364
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| タイトル: | Effect of oral L-arginine administration on exhaled nitric oxide (no) concentration in healthy volunteers |
| その他のタイトル: | Effect of arginine administration on exhaled NO |
| 著者: | Ogata, Hiroshi
Yatabe, Midori
Misaka, Shingen
Shikama, Yayoi
Sato, Suguru
Munakata, Mitsuru
Kimura, Junko |
| 学内所属: | 薬理学講座
呼吸器内科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 59 |
| 号: | 1 |
| 開始ページ: | 43 |
| 終了ページ: | 48 |
| 発行日: | 2013年 |
| 抄録: | We previously reported a case of pulmonary hypertension, where the symptoms were improved by oral L-arginine (arginine) administration. Arginine may increase nitric oxide (NO) production in the pulmonary artery. Exhaled NO may reflect pulmonary artery NO production. It has been demonstrated that exhaled NO concentration is higher in patients with allergic diseases, but whether oral arginine administration alters exhaled NO is unknown. Therefore, in this study, we investigated whether oral arginine administration increases exhaled NO among healthy volunteers with and without a history of allergy.Eleven subjects were given a single oral dose (200 mg/kg) of arginine, and their plasma arginine concentrations and exhaled NO were measured up to 150 minutes. Baseline values of exhaled NO concentration were significantly higher in those with a history of allergy (56.4±20.3 ppb, n=5, P< 0.05) than those without (16.8±4.0 ppb, n=6). Oral arginine increased exhaled NO, which peaked at 60 minutes after the administration in those with a history of allergy (85.2±44.8 ppb, n=5). However, the increase in exhaled NO was not significant compared to the baseline values. In contrast, plasma arginine concentration was increased significantly by arginine administration (P< 0.01), regardless of an allergy history. These results suggested that the difference in exhaled NO concentration was not due to a difference in arginine absorption.Serum IgE level was significantly higher in the group with a history of allergy. Eosinophils and white blood cells were within normal range in all subjects. We conclude that oral arginine administration does not significantly increase exhaled NO, regardless of allergy history. However, as arginine administration has been reported to be effective in patients with pulmonary hypertension, it will be necessary to test exhaled NO in subjects with pulmonary hypertension in the future. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/364 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/364/1/FksmJMedSci_59_p43.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.59.43 |
| PubMed番号: | 23842514 |
| 関連ページ: | http://dx.doi.org/10.5387/fms.59.43 |
| 権利情報: | © 2013 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.59 (2013)
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