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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.58 (2012) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/341
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| タイトル: | A reduction of coronary flow reserve is associated with chronic kidney disease and long-term cardio-cerebrovascular events in patients with non-obstructive coronary artery disease and vasospasm |
| その他のタイトル: | CFR is impaired in CKD and vascular events |
| 著者: | Sakamoto, Nobuo
Iwaya, Shoji
Owada, Takashi
Nakamura, Yuichi
Yamauchi, Hiroyuki
Hoshino, Yasuto
Mizukami, Hiroyuki
Sugimoto, Koichi
Yamaki, Takayoshi
Kunii, Hiroyuki
Nakazato, Kazuhiko
Suzuki, Hitoshi
Saitoh, Shu-Ichi
Takeishi, Yasuchika |
| 学内所属: | 循環器・血液内科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 58 |
| 号: | 2 |
| 開始ページ: | 136 |
| 終了ページ: | 143 |
| 発行日: | 2012年 |
| 抄録: | Background: Coronary flow reserve (CFR) provides essential information about the coronary microvasculature. Chronic kidney disease (CKD) is a risk factor for cardio-cerebrovascular diseases. We hypothesized that low CFR is associated with CKD and long-term cardio-cerebrovascular events in the patients without obstructive coronary artery diseases and vasospasm. Method and Results: In this study, 73 patients suspected with coronary artery disease but had no epicardial coronary stenosis and vasospasm were enrolled. There were 13 CKD patients and CFR was measured using the Doppler flow wire methods in the left anterior descending artery. CFR was significantly lower in CKD group than non-CKD group (3.13±0.6 vs. 4.00±1.1, P=0.007). From multivariate logistic regression analysis, the independent factor associated with the presence of CKD was only CFR (odds ratio 3.85, 95% confidence interval 1.27-11.70, P=0.017). In the patients with low CFR (≤ 2.8), cardio-cerebrovascular events were more common than those with normal CFR (CFR > 2.8). Besides, in the patients who had both low CFR and CKD, long-term cardio-cerebrovascular events were more likely to occur than those with normal CFR or non-CKD. Conclusions: Our data suggest that low CFR is associated with CKD and cardio-cerebrovascular events in the patients without coronary stenosis and vasospasm. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/341 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/341/1/FksmJMedSci_58_p136.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.58.136 |
| PubMed番号: | 23237869 |
| 異版(出版者版等): | http://dx.doi.org/10.5387/fms.58.136 |
| 権利情報: | © 2012 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.58 (2012)
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