|
福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.58 (2012) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/336
|
| タイトル: | The role of HMGA2 in the proliferation and expansion of a hematopoietic cell in myeloproliferative neoplasms |
| その他のタイトル: | Hematopoietic clonal expansion in MPN by HMGA2 |
| 著者: | Ikeda, Kazuhiko
Ogawa, Kazuei
Takeishi, Yasuchika |
| 学内所属: | 循環器・血液内科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 58 |
| 号: | 2 |
| 開始ページ: | 91 |
| 終了ページ: | 100 |
| 発行日: | 2012年 |
| 抄録: | Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are characterized by clonal proliferative hematopoiesis with increased blood cell count. Clonal expansion mechanisms in MPN and related disorders such as myelodysplastic syndromes (MDS) remain to be elucidated. Although mutations in the JAK2 gene lead to a proliferative hematopoiesis in majority of MPN and some MDS, the mutation alone does not cause a clonal expansion. In addition to JAK2 mutations, several genetic abnormalities, including TET2 and polycomb group genes involving epigenetic regulation have been reported in patients with MPN. Moreover, overexpression of HMGA2 due to removal of specific sites in its 3' untranslated region for regulatory let-7 micro RNAs may contribute to the proliferative hematopoiesis with conferring a growth advantage at the level of a hematopoietic stem cell in some cases with MPN. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/336 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/336/1/FksmJMedSci_58_p91.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.58.91 |
| PubMed番号: | 23237864 |
| 異版(出版者版等): | http://dx.doi.org/10.5387/fms.58.91 |
| 権利情報: | © 2012 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.58 (2012)
|
このリポジトリに保管されているアイテムは、他に指定されている場合を除き、著作権により保護されています。
|
