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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.70 (2024) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/2232
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| タイトル: | Differentiation of ovarian serous carcinoma from ovarian clear cell carcinoma using a 10-gene signature selected by comprehensive gene expression analysis |
| 著者: | Nomura, Shinji
Watanabe, Takafumi
Honma, Reiko
Matsukura, Susumu
Ito, Emi
Imai, Jun-Ichi
Kiko, Yuichiro
Suzuki, Osamu
Hashimoto, Yuko
Kojima, Manabu
Furukawa, Shigenori
Soeda, Shu
Watanabe, Shinya
Fujimori, Keiya |
| 学内所属: | 産科婦人科学講座
医療−産業トランスレーショナルリサーチセンター
病理病態診断学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 70 |
| 号: | 2 |
| 開始ページ: | 65 |
| 終了ページ: | 73 |
| 発行日: | 2024年 |
| 抄録: | Aim: Ovarian serous carcinoma (OSC) and ovarian clear cell carcinoma (OCCC) are two major histological types of epithelial ovarian carcinoma (EOC), each with different biological features and clinical behaviors. Although immunostaining is commonly used for differential diagnosis between OSC and OCCC, correct identification of EOC with mixed-type histology is sometimes a diagnostic challenge. The aim of the present study was to explore candidate genes as potential diagnostic biomarkers that distinguish OSC from OCCC. Methods: A total of 57 surgical specimens were obtained from EOC patients who had previously undergone primary debulking surgery. Total RNAs were extracted from fresh-frozen tissues of EOC patients, and were used for comprehensive gene expression analysis using DNA microarray technology. Results: Ten candidate genes, FXYD2, TMEM101, GABARAPL1, ARG2, GLRX, RBPMS, GDF15, PPP1R3B, TOB1, and GSTM3 were up-regulated in OCCC compared to OSC. All EOC patients were divided into two groups according to hierarchical clustering using a 10-gene signature. Conclusion: Our data suggest that the 10 candidate genes would be an excellent marker for distinguishing OSC from OCCC. Furthermore, the molecular signatures of the 10 genes may enlighten us on the differences in carcinogenesis, and provide a theoretical basis for OCCC's resistance to chemotherapy in the future. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/2232 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/2232/1/FksmJMedSci_70_p65.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.23-00011 |
| PubMed番号: | 38494731 |
| 関連ページ: | https://doi.org/10.5387/fms.23-00011 |
| 権利情報: | © 2024 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| 権利情報: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| 出現コレクション: | Vol.70 (2024)
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