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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.70 (2024) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/2209
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| タイトル: | Cellular carcinogenesis in preleukemic conditions: drivers and defenses |
| 著者: | Ueda, Koki
Ikeda, Kazuhiko |
| 学内所属: | 輸血・移植免疫学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 70 |
| 号: | 1 |
| 開始ページ: | 11 |
| 終了ページ: | 24 |
| 発行日: | 2024年 |
| 抄録: | Acute myeloid leukemia (AML) arises from preleukemic conditions. We have investigated the pathogenesis of typical preleukemia, myeloproliferative neoplasms, and clonal hematopoiesis. Hematopoietic stem cells in both preleukemic conditions harbor recurrent driver mutations; additional mutation provokes further malignant transformation, leading to AML onset. Although genetic alterations are defined as the main cause of malignant transformation, non-genetic factors are also involved in disease progression. In this review, we focus on a non-histone chromatin protein, high mobility group AT-hook2 (HMGA2), and a physiological p53 inhibitor, murine double minute X (MDMX). HMGA2 is mainly overexpressed by dysregulation of microRNAs or mutations in polycomb components, and provokes expansion of preleukemic clones through stem cell signature disruption. MDMX is overexpressed by altered splicing balance in myeloid malignancies. MDMX induces leukemic transformation from preleukemia via suppression of p53 and p53-independent activation of WNT/β-catenin signaling. We also discuss how these non-genetic factors can be targeted for leukemia prevention therapy. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/2209 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/2209/1/FksmJMedSci_70_p11.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2023-17 |
| PubMed番号: | 37952978 |
| 関連ページ: | https://doi.org/10.5387/fms.2023-17 |
| 権利情報: | © 2024 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| 権利情報: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| 出現コレクション: | Vol.70 (2024)
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