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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.49 (2003) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/136
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| タイトル: | Effects of nitric oxide donors on non-pregnant and pregnant rat uterine and aortic smooth muscle |
| その他のタイトル: | Effect of no on uterus and aorta |
| 著者: | Okawa, Toshiaki
Sato, Akira
Syal, Ashu S
Vedernikov, Yuri P
Saade, George R
Garfield, Robert E |
| 学内所属: | 産科婦人科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 49 |
| 号: | 1 |
| 開始ページ: | 23 |
| 終了ページ: | 32 |
| 発行日: | 2003年6月 |
| 抄録: | OBJECTIVE: To compare the effects of nitric oxide (NO) donors, diethylamine/nitric oxide (DEA/NO) and nitroglycerin (NTG), on isolated uterine and aortic tissues from non-pregnant, mid and late pregnant rats. METHODS: The uterus and thoracic aorta were obtained from non-pregnant (estrous cycle) and pregnant Sprague-Dawley rats on day 14 and day 21. The uterine and aortic rings were incubated in organ chambers filled with Krebs-Henseleit solution bubbled with 5% CO2 in air for isometric tension recordings. Cumulative concentration-response relationships to DEA/NO and NTG were obtained in the aortic rings contracted with phenylephrine and in spontaneously contracting uterine rings. RESULTS: The sensitivity and the maximal inhibitory effects of DEA/NO did not differ in aortic tissues of any group. DEA/NO-induced Maximal inhibition of spontaneous contractions of uterine tissues from mid-pregnant rats was greater (although not significantly) than in the tissues from non-pregnant animals (with similar sensitivity), but it was significantly depressed in tissues from late pregnant rats. The sensitivity to and maximal inhibitory effects of NTG were less in aortic tissues from late pregnant versus mid-pregnant and non-pregnant rats. In uterine tissues from late pregnant rats the effect of NTG was negligible. The inhibitory action of both NO donors was much more pronounced in aortic versus uterine tissues. CONCLUSIONS: Uterine smooth muscle is less sensitive than vascular smooth muscle to NO. Uterine smooth muscle from late pregnant animals demonstrates refractoriness to both DEA/NO and NTG, while vascular smooth muscle from late pregnant animals demonstrates refractoriness to NTG, but not to DEA/NO. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/136 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/136/1/FksmJMedSci_49_p23.pdf |
| ISSN: | 0016-2590 |
| DOI: | 10.5387/fms.49.23 |
| PubMed番号: | 14603949 |
| 関連ページ: | https://doi.org/10.5387/fms.49.23 |
| 権利情報: | © 2003 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.49 (2003)
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