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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.66 (2020) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/1311
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| タイトル: | Autophagy is involved in the sclerotic phase of systemic sclerosis |
| 著者: | Mori, Tatsuhiko
Tamura, Naoki
Waguri, Satoshi
Yamamoto, Toshiyuki |
| 学内所属: | 皮膚科学講座
解剖・組織学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 66 |
| 号: | 1 |
| 開始ページ: | 17 |
| 終了ページ: | 24 |
| 発行日: | 2020年 |
| 抄録: | Autophagy is an essential intracellular self-degradation system, and is known to maintain the homeostatic balance between the synthesis, degradation, and recycling of cellular proteins and organelles. Recent studies have suggested a possible role of autophagy in systemic sclerosis (SSc); however, differences in autophagy among pathological phases of SSc have not yet been examined. Therefore, in the current study we investigated the expression pattern of an autophagosome marker protein, microtubule-associated protein 1 light chain 3 (LC3) in the lesional skin of a murine model and human SSc. In bleomycin-induced mouse scleroderma skin, the number of LC3-positive puncta was significantly higher than that in phosphate buffered salts-injected control skin after 4 weeks of treatment. Such an increase, however, was not observed in the skin after 2 weeks of bleomycin treatment, in which few myofibroblasts were detected. In the sclerotic phase of SSc patients, the number of LC3-positive puncta in the lower dermis was significantly higher than in the upper dermis. It was also significantly higher than in the lower dermis of the control patients. No increase in LC3-positive puncta was observed in the skin from SSc patients in edematous phase, in which myofibroblasts were hardly detected. These results suggest that changes in the autophagic degradation system reflect a skin remodeling process that leads to fibrosis. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/1311 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/1311/1/FksmJMedSci_66_p17.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2019-28 |
| PubMed番号: | 32281584 |
| 関連ページ: | https://doi.org/10.5387/fms.2019-28 |
| 権利情報: | © 2020 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| 権利情報: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| 出現コレクション: | Vol.66 (2020)
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