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Vol.58 (2012) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/341

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Title: A reduction of coronary flow reserve is associated with chronic kidney disease and long-term cardio-cerebrovascular events in patients with non-obstructive coronary artery disease and vasospasm
Other Titles: CFR is impaired in CKD and vascular events
Authors: Sakamoto, Nobuo
Iwaya, Shoji
Owada, Takashi
Nakamura, Yuichi
Yamauchi, Hiroyuki
Hoshino, Yasuto
Mizukami, Hiroyuki
Sugimoto, Koichi
Yamaki, Takayoshi
Kunii, Hiroyuki
Nakazato, Kazuhiko
Suzuki, Hitoshi
Saitoh, Shu-Ichi
Takeishi, Yasuchika
Affiliation: 循環器・血液内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 58
Issue: 2
Start page: 136
End page: 143
Issue Date: 2012
Abstract: Background: Coronary flow reserve (CFR) provides essential information about the coronary microvasculature. Chronic kidney disease (CKD) is a risk factor for cardio-cerebrovascular diseases. We hypothesized that low CFR is associated with CKD and long-term cardio-cerebrovascular events in the patients without obstructive coronary artery diseases and vasospasm. Method and Results: In this study, 73 patients suspected with coronary artery disease but had no epicardial coronary stenosis and vasospasm were enrolled. There were 13 CKD patients and CFR was measured using the Doppler flow wire methods in the left anterior descending artery. CFR was significantly lower in CKD group than non-CKD group (3.13±0.6 vs. 4.00±1.1, P=0.007). From multivariate logistic regression analysis, the independent factor associated with the presence of CKD was only CFR (odds ratio 3.85, 95% confidence interval 1.27-11.70, P=0.017). In the patients with low CFR (≤ 2.8), cardio-cerebrovascular events were more common than those with normal CFR (CFR > 2.8). Besides, in the patients who had both low CFR and CKD, long-term cardio-cerebrovascular events were more likely to occur than those with normal CFR or non-CKD. Conclusions: Our data suggest that low CFR is associated with CKD and cardio-cerebrovascular events in the patients without coronary stenosis and vasospasm.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/341
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/341/1/FksmJMedSci_58_p136.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.58.136
PubMed ID: 23237869
Other version: http://dx.doi.org/10.5387/fms.58.136
Rights: © 2012 The Fukushima Society of Medical Science
Appears in Collections:Vol.58 (2012)

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