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Vol.58 (2012) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/336

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Title: The role of HMGA2 in the proliferation and expansion of a hematopoietic cell in myeloproliferative neoplasms
Other Titles: Hematopoietic clonal expansion in MPN by HMGA2
Authors: Ikeda, Kazuhiko
Ogawa, Kazuei
Takeishi, Yasuchika
Affiliation: 循環器・血液内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 58
Issue: 2
Start page: 91
End page: 100
Issue Date: 2012
Abstract: Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are characterized by clonal proliferative hematopoiesis with increased blood cell count. Clonal expansion mechanisms in MPN and related disorders such as myelodysplastic syndromes (MDS) remain to be elucidated. Although mutations in the JAK2 gene lead to a proliferative hematopoiesis in majority of MPN and some MDS, the mutation alone does not cause a clonal expansion. In addition to JAK2 mutations, several genetic abnormalities, including TET2 and polycomb group genes involving epigenetic regulation have been reported in patients with MPN. Moreover, overexpression of HMGA2 due to removal of specific sites in its 3' untranslated region for regulatory let-7 micro RNAs may contribute to the proliferative hematopoiesis with conferring a growth advantage at the level of a hematopoietic stem cell in some cases with MPN.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/336
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/336/1/FksmJMedSci_58_p91.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.58.91
PubMed ID: 23237864
Other version: http://dx.doi.org/10.5387/fms.58.91
Rights: © 2012 The Fukushima Society of Medical Science
Appears in Collections:Vol.58 (2012)

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