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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.58 (2012) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/336
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| Title: | The role of HMGA2 in the proliferation and expansion of a hematopoietic cell in myeloproliferative neoplasms |
| Other Titles: | Hematopoietic clonal expansion in MPN by HMGA2 |
| Authors: | Ikeda, Kazuhiko
Ogawa, Kazuei
Takeishi, Yasuchika |
| Affiliation: | 循環器・血液内科学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 58 |
| Issue: | 2 |
| Start page: | 91 |
| End page: | 100 |
| Issue Date: | 2012 |
| Abstract: | Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are characterized by clonal proliferative hematopoiesis with increased blood cell count. Clonal expansion mechanisms in MPN and related disorders such as myelodysplastic syndromes (MDS) remain to be elucidated. Although mutations in the JAK2 gene lead to a proliferative hematopoiesis in majority of MPN and some MDS, the mutation alone does not cause a clonal expansion. In addition to JAK2 mutations, several genetic abnormalities, including TET2 and polycomb group genes involving epigenetic regulation have been reported in patients with MPN. Moreover, overexpression of HMGA2 due to removal of specific sites in its 3' untranslated region for regulatory let-7 micro RNAs may contribute to the proliferative hematopoiesis with conferring a growth advantage at the level of a hematopoietic stem cell in some cases with MPN. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/336 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/336/1/FksmJMedSci_58_p91.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.58.91 |
| PubMed ID: | 23237864 |
| Other version: | http://dx.doi.org/10.5387/fms.58.91 |
| Rights: | © 2012 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.58 (2012)
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