|
福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.58 (2012) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/319
|
| タイトル: | Local application of nucleus pulposus induces expression of P2X_3 in rat dorsal root ganglion cells |
| 著者: | Takahashi Sato, Kaoru
Satoh, Koichiro
Sekiguchi, Miho
Kikuchi, Shin-Ichi
Konno, Shin-Ichi
Murakawa, Masahiro
Rydevik, Björn
Olmarker, Kjell |
| 学内所属: | 麻酔科学講座
整形外科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 58 |
| 号: | 1 |
| 開始ページ: | 17 |
| 終了ページ: | 21 |
| 発行日: | 2012年 |
| 抄録: | The P2X_3 receptor is a ligand-gated cation channel that is activated by extra cellular adenosine triphosphate (ATP) found in the dorsal root, trigeminal and nodose ganglia. It is one of the receptors transmitting nociceptive information of injuries and inflammation of the periphery by endogenous ATP released from damaged cells. The present study was performed in order to evaluate if there was an increased expression of P2X_3-immunoreactivity in dorsal root ganglion (DRG) neurons after experimental disc herniation. There were four groups: exposure of the left L4 dorsal root ganglion and incision of the L4-L5 disc, exposure and slight displacement of the left L4 dorsal ganglion, sham exposure of the L4 dorsal root ganglion, and normal. Seven days after surgery, the DRG's were collected, sectioned and stained immunohistochemically for the P2X_3 receptor. The expression of P2X_3 increased significantly following incision of the L4-5 disc compared to the normal group. Sham surgery induced a minor, although statistically significant increase. Mechanical displacement did not induce any increased expression of the receptors. The study demonstrates that expression of the P2X_3 receptors in the DRG may be induced by local application of nucleus pulposus. This may increase our understanding of the pathophysiologic mechanisms related to disc herniation and sciatica. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/319 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/319/1/FksmJMedSci_58_p17.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.58.17 |
| PubMed番号: | 22790888 |
| 異版(出版者版等): | http://dx.doi.org/10.5387/fms.58.17 |
| 権利情報: | © 2012 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.58 (2012)
|
このリポジトリに保管されているアイテムは、他に指定されている場合を除き、著作権により保護されています。
|
