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Vol.70 (2024) >

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Title: Differentiation of ovarian serous carcinoma from ovarian clear cell carcinoma using a 10-gene signature selected by comprehensive gene expression analysis
Authors: Nomura, Shinji
Watanabe, Takafumi
Honma, Reiko
Matsukura, Susumu
Ito, Emi
Imai, Jun-Ichi
Kiko, Yuichiro
Suzuki, Osamu
Hashimoto, Yuko
Kojima, Manabu
Furukawa, Shigenori
Soeda, Shu
Watanabe, Shinya
Fujimori, Keiya
Affiliation: 産科婦人科学講座
医療−産業トランスレーショナルリサーチセンター
病理病態診断学講座
Source title: Fukushima Journal of Medical Science
Volume: 70
Issue: 2
Start page: 65
End page: 73
Issue Date: 2024
Abstract: Aim: Ovarian serous carcinoma (OSC) and ovarian clear cell carcinoma (OCCC) are two major histological types of epithelial ovarian carcinoma (EOC), each with different biological features and clinical behaviors. Although immunostaining is commonly used for differential diagnosis between OSC and OCCC, correct identification of EOC with mixed-type histology is sometimes a diagnostic challenge. The aim of the present study was to explore candidate genes as potential diagnostic biomarkers that distinguish OSC from OCCC. Methods: A total of 57 surgical specimens were obtained from EOC patients who had previously undergone primary debulking surgery. Total RNAs were extracted from fresh-frozen tissues of EOC patients, and were used for comprehensive gene expression analysis using DNA microarray technology. Results: Ten candidate genes, FXYD2, TMEM101, GABARAPL1, ARG2, GLRX, RBPMS, GDF15, PPP1R3B, TOB1, and GSTM3 were up-regulated in OCCC compared to OSC. All EOC patients were divided into two groups according to hierarchical clustering using a 10-gene signature. Conclusion: Our data suggest that the 10 candidate genes would be an excellent marker for distinguishing OSC from OCCC. Furthermore, the molecular signatures of the 10 genes may enlighten us on the differences in carcinogenesis, and provide a theoretical basis for OCCC's resistance to chemotherapy in the future.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/2232
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/2232/1/FksmJMedSci_70_p65.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.23-00011
PubMed ID: 38494731
Related Page: https://doi.org/10.5387/fms.23-00011
Rights: © 2024 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0/
Appears in Collections:Vol.70 (2024)

Files in This Item:

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FksmJMedSci_70_p65.pdf1.61 MBAdobe PDFDownload

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