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Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/211

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Title: RETRACTED: Effects of olprinone on neuromuscular blockade caused by vecuronium
Other Titles: Olprinone and vecuronium
Authors: Katayama, Takaaki
Saitoh, Yuhji
Nemoto, Chiaki
Hirama, Takahiro
Isosu, Tsuyoshi
Murakawa, Masahiro
Affiliation: 麻酔科学講座
Source title: Fukushima Journal of Medical Science
Volume: 53
Issue: 2
Start page: 61
End page: 69
Issue Date: Dec-2007
Abstract: We studied the effect of olprinone on neuromuscular blockade caused by vecuronium. Thirty women undergoing nitrous oxide-oxygen-isoflurane anesthesia were randomly divided into olprinone (n=15) or control group (n=15). In the olprinone group, the patients received an intravenous initial loading dose of olprinone at a rate of 2 microg/kg/minute for 5 minutes, followed by a continuous infusion of olprinone at 0.3 microg/kg/minute. In the control group, the patients received normal saline. Thirty minutes after the beginning of the infusion of olprinone or normal saline, vecuronium (0.1 mg/kg) was administered. The degree of neuromuscular blockade was monitored electromyographically at the adductor pollicis muscle. The time to the onset of neuromuscular blockade, and to the return of the first, second, third, or fourth response in train-of-four (TOF; T1, T2, T3, or T4, respectively), and the time course of recovery of T1/control did not differ significantly between the groups. After 50-70 minutes of vecuronium, the TOF ratio (T4/T1) in the olprinone group was significantly higher than in the control group. During this period, the mean TOF ratios in the control and olprinone groups were 0.15-0.39 and 0.40-0.57, respectively. In conclusion, olprinone accelerates the recovery of the TOF ratio, and the quickening effect of olprinone on the recovery of the TOF ratio may be apparent 50-70 minutes after vecuronium in anesthetized patients receiving vecuronium.
Description: This article has been retracted. Retraction notice: Fukushima Journal of Medical Science. 2017; 63(2):126. 撤回論文
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/211
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/211/3/FksmJMedSci_53_p61_RETRACTED.pdf
ISSN: 0016-2590
PubMed ID: 18402286
Rights: © 2007 The Fukushima Society of Medical Science
Appears in Collections:Vol.53 (2007)

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FksmJMedSci_53_p61_RETRACTED.pdf823.14 kBAdobe PDFDownload

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