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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.68 (2022) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/1932
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| Title: | Successful management of unstable angina in a ravulizumab-treated patient with paroxysmal nocturnal hemoglobinuria |
| Authors: | Takahashi, Hiroshi
Mori, Hirotaka
Fukatsu, Masahiko
Sano, Takahiro
Harada, Kayo
Oikawa, Masayoshi
Takeishi, Yasuchika
Kimura, Satoshi
Ohkawara, Hiroshi
Shichishima, Tsutomu
Ikezoe, Takayuki |
| Affiliation: | 血液内科学講座
循環器内科学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 68 |
| Issue: | 3 |
| Start page: | 175 |
| End page: | 178 |
| Issue Date: | 2022 |
| Abstract: | Ravulizumab is an anti-C5 antibody approved for treating paroxysmal nocturnal hemoglobinuria (PNH). In August 2019, a 77-year-old Japanese man with PNH, who had been on ravulizumab treatment for 2 years, was hospitalized for chest discomfort and malaise. Electrocardiography identified a right bundle block, and elevated serum troponin I and d-dimer suggested ischemic heart disease. Cardiac catheterization revealed severe stenosis in the left anterior descending coronary artery, and intracoronary stenting relieved his chest discomfort. The final diagnosis was unstable angina unrelated to ravulizumab, and the patient's ravulizumab treatment was uninterrupted with no significant complications of PNH. This case report highlights the importance of continuing complement inhibition therapy during acute coronary events. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/1932 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/1932/1/FksmJMedSci_68_p175.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2022-16 |
| PubMed ID: | 36130907 |
| Related Page: | https://doi.org/10.5387/fms.2022-16 |
| Rights: | © 2022 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| Rights: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| Appears in Collections: | Vol.68 (2022)
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