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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.68 (2022) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/1930
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| Title: | Association between the presence of bacteria in prostate tissue and histopathology in biopsies from men not complaining of lower urinary tract symptoms |
| Authors: | Honda-Takinami, Ruriko
Hata, Junya
Matsuoka, Kanako
Hoshi, Seiji
Koguchi, Tomoyuki
Sato, Yuichi
Akaihata, Hidenori
Kataoka, Masao
Ogawa, Soichiro
Nishiyama, Kyoko
Suzutani, Tatsuo
Kojima, Yoshiyuki |
| Affiliation: | 泌尿器科学講座
微生物学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 68 |
| Issue: | 3 |
| Start page: | 161 |
| End page: | 167 |
| Issue Date: | 2022 |
| Abstract: | Objective: To investigate the presence of bacteria in prostate tissue, and relationships between the bacteria and histopathological findings. Methods: Samples were collected from prostate biopsy patients with no obvious lower urinary tract symptoms (LUTS). Detection and identification of bacterial species in the prostate tissues were performed with PCR for 16SrDNA and DNA sequencing. Histopathology was also evaluated. LUTS and lower urinary tract function were assessed by questionnaires, uroflowmetry, and ultrasonography. Results: DNA was extracted from 97 prostate biopsies, with 5 bacterial species detected among samples from 7 patients (7.2%). The stroma-to-gland ratio in the prostate tissues from patients with bacteria was lower than in those without bacteria (p < 0.01). Glandular epithelial hyperplasia was also identified in the prostates harboring bacteria. International Prostate Symptom Score (IPSS), IPSS-quality of life (IPSS-QOL), Overactive Bladder Symptom Score (OABSS), maximum flow rate, urine volume by uroflowmetry, and post-voided residual urine were not significantly different when comparing patients with and without bacteria in their prostate samples. Conclusions: The present study demonstrated that 7.2% of men without obvious LUTS had bacteria in their prostate tissues. The presence of such bacteria might induce glandular hyperplasia and contribute to pathological changes in the early stages of benign prostate enlargement before affecting LUTS. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/1930 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/1930/1/FksmJMedSci_68_p161.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2022-34 |
| PubMed ID: | 36372441 |
| Related Page: | https://doi.org/10.5387/fms.2022-34 |
| Rights: | © 2022 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license. |
| Rights: | https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| Appears in Collections: | Vol.68 (2022)
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