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Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/1586

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Title: Total transferrin in cerebrospinal fluid is a novel biomarker for spontaneous intracranial hypotension
Authors: Iijima, Junko
Hoshi, Kyoka
Ito, Hiromi
Kanno, Mayumi
Murakami, Yuta
Takahashi, Koichi
Matsumoto, Kana
Yamaguchi, Yoshiki
Nakajima, Madoka
Miyajima, Masakazu
Arai, Hajime
Kanai, Mitsuyasu
Kitazume, Shinobu
Honda, Takashi
Hashimoto, Yasuhiro
Affiliation: 生化学講座
Source title: Fukushima Journal of Medical Science
Volume: 67
Issue: 2
Start page: 64
End page: 70
Issue Date: 2021
Abstract: Spontaneous intracranial hypotension (SIH) is caused by cerebrospinal fluid (CSF) leakage. Patients with SIH experience postural headaches, nausea, etc., due to CSF hypovolemia. Imaging studies and clinical examinations, such as radioisotope (RI) scintigraphy, are useful for diagnosing SIH. However, 20-30% of patients do not show typical morphology and clinical test results. We previously reported that CSF contains transferrin (Tf) isoforms:"brain-type" Tf derived from the choroid plexus and "serum-type" Tf derived from blood. We showed that both isoforms increased in the CSF of patients with SIH by Western blotting. In the present study, we demonstrate that conventional ELISA for quantifying total Tf is useful for diagnosing SIH more accurately than Western blotting. In addition, SIH with chronic subdural hematoma (CSDH) was also accurately diagnosed. Total Tf in the CSF can serve as a useful biomarker for diagnosing SIH with or without CSDH.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/1586
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/1586/1/FksmJMedSci_67_p64.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2020-19
PubMed ID: 34373399
Related Page: https://doi.org/10.5387/fms.2020-19
Rights: © 2021 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0/
Appears in Collections:Vol.67 (2021)

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