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Vol.67 (2021) >

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Title: Orthogonal antibody testing for COVID-19 among healthcare workers in a non-epidemic place and time: Japan's Iwate Prefecture, May 18-31, 2020
Authors: Nakamura, Akihiro
Sato, Ryoichi
Ando, Sanae
Oana, Natsuko
Nozaki, Eiji
Endo, Hideaki
Miyate, Yoshiharu
Soma, Jun
Miyata, Go
Source title: Fukushima Journal of Medical Science
Volume: 67
Issue: 1
Start page: 27
End page: 32
Issue Date: 2021
Abstract: Of the 47 prefectures in Japan, Iwate had the fewest cases of coronavirus disease 2019 (COVID-19), with the first diagnosis officially confirmed on July 28, 2020. A baseline serological survey of COVID-19 antibodies is essential to accurately evaluate an epidemic outbreak. The primary purpose of this study was to determine pre-epidemic prevalence of COVID-19 antibodies among healthcare workers, using two laboratory-based quantitative tests. In addition, a point-of-care (POC) qualitative test, rapid, simple, and convenient for primary care clinics, was compared with the laboratory-based tests. All antibody tests were performed on serum from 1,000 healthcare workers (mean age, 40 ± 11 years) in Iwate Prefectural Central Hospital, May 29-31, 2020. A COVID-19 case was defined as showing positive results in both laboratory-based quantitative tests. None of 1,000 samples had positive results in both of the laboratory immunoassays. The POC test showed positive results in 33 of 1,000 samples (3.3%) (95% confidence interval:2.19-4.41), but no samples were simultaneously positive in both laboratory-based tests. In conclusion, COVID-19 cases were not serologically confirmed by a baseline control study of healthcare workers at our hospital in late May, 2020. Moreover, the POC qualitative test may offer no advantage in areas with very low prevalence of COVID-19, due to higher false-positive reactions compared with laboratory-based quantitative immunoassays.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/1381
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/1381/1/FksmJMedSci_67_p27.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2020-21
PubMed ID: 33642419
Related Page: https://doi.org/10.5387/fms.2020-21
Rights: © 2021 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0/
Appears in Collections:Vol.67 (2021)

Files in This Item:

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FksmJMedSci_67_p27.pdf449.05 kBAdobe PDFDownload

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