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Vol.66 (2020) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/1311

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Title: Autophagy is involved in the sclerotic phase of systemic sclerosis
Authors: Mori, Tatsuhiko
Tamura, Naoki
Waguri, Satoshi
Yamamoto, Toshiyuki
Affiliation: 皮膚科学講座
解剖・組織学講座
Source title: Fukushima Journal of Medical Science
Volume: 66
Issue: 1
Start page: 17
End page: 24
Issue Date: 2020
Abstract: Autophagy is an essential intracellular self-degradation system, and is known to maintain the homeostatic balance between the synthesis, degradation, and recycling of cellular proteins and organelles. Recent studies have suggested a possible role of autophagy in systemic sclerosis (SSc); however, differences in autophagy among pathological phases of SSc have not yet been examined. Therefore, in the current study we investigated the expression pattern of an autophagosome marker protein, microtubule-associated protein 1 light chain 3 (LC3) in the lesional skin of a murine model and human SSc. In bleomycin-induced mouse scleroderma skin, the number of LC3-positive puncta was significantly higher than that in phosphate buffered salts-injected control skin after 4 weeks of treatment. Such an increase, however, was not observed in the skin after 2 weeks of bleomycin treatment, in which few myofibroblasts were detected. In the sclerotic phase of SSc patients, the number of LC3-positive puncta in the lower dermis was significantly higher than in the upper dermis. It was also significantly higher than in the lower dermis of the control patients. No increase in LC3-positive puncta was observed in the skin from SSc patients in edematous phase, in which myofibroblasts were hardly detected. These results suggest that changes in the autophagic degradation system reflect a skin remodeling process that leads to fibrosis.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/1311
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/1311/1/FksmJMedSci_66_p17.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.2019-28
PubMed ID: 32281584
Related Page: https://doi.org/10.5387/fms.2019-28
Rights: © 2020 The Fukushima Society of Medical Science. This article is licensed under a Creative Commons [Attribution-NonCommercial-ShareAlike 4.0 International] license.
Rights: https://creativecommons.org/licenses/by-nc-sa/4.0/
Appears in Collections:Vol.66 (2020)

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FksmJMedSci_66_p17.pdf2.55 MBAdobe PDFDownload

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