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Vol.65 (2019) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/776

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Title: Clinical usefulness of ramucirumab plus paclitaxel for unresectable and recurrent gastric cancer
Authors: Hayase, Suguru
Yamada, Leo
Ujiie, Daisuke
Nirei, Azuma
Tada, Takeshi
Hanayama, Hiroyuki
Monma, Tomoyuki
Saze, Zenichiro
Ohki, Shinji
Kono, Koji
Affiliation: 消化管外科学講座
Source title: Fukushima Journal of Medical Science
Volume: 65
Issue: 1
Start page: 6
End page: 12
Issue Date: 2019
Abstract: Introduction Recently in Japan, Ramucirumab (RAM) became the first anti-angiogenic agent to be approved for second-line treatment of gastric cancer. In the present study, we aimed to evaluate the efficacy and safety of RAM plus paclitaxel (PTX) in patients with unresectable and recurrent gastric cancer in our institution. Patients and Methods The subjects were 11 patients with unresectable and recurrent gastric cancer who received RAM plus PTX as a second- or later-line treatment at our hospital between June 2015 and September 2017, after the failure of previously-attempted treatments. We assessed the efficacy and safety of RAM plus PTX, and also compared them between patients aged <75 years (n=6) and those aged ≥75 (n=5), by performing a retrospective analysis based on the data obtained from daily clinical practice for gastric cancer treatment. Results Objective tumor response was observed in one of the 11 patients (9.1%) with partial response, and disease control was seen in the remaining 10 (90.9%). The median overall survival (OS) and progression-free survival (PFS) of the patients were 20.8 months (95% CI 7.8-NA (not applicable)) and 11.3 months (95% CI 6.5-NA), respectively. There were no serious adverse events. The median OS for the <75 years group and ≥75 years group was NA (due to short follow-up period) and 20.8 months (p = 0.336), respectively, and their respective median PFS rates were 9.4 and 11.3 months (p = 0.492). The difference of rate of adverse events was not significant between the two age groups in the present study, though the number of adverse events was not sufficient. Conclusion The results of the present study suggest that the combination chemotherapy of RAM and PTX was effective in unresectable and recurrent gastric cancer patients as a second- or later-line therapy, and has been shown to be safe and feasible in elderly patients.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/776
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/776/1/FksmJMedSci_65_p6.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.2018-12
PubMed ID: 30996218
Related Page: https://doi.org/10.5387/fms.2018-12
Rights: © 2019 The Fukushima Society of Medical Science
Appears in Collections:Vol.65 (2019)

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FksmJMedSci_65_p6.pdf266.57 kBAdobe PDFDownload

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