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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
A 医学部 = School of Medicine >
a10 学術雑誌論文等 = Journal Article >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/759
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| タイトル: | Developmental regulation of notochord-derived repulsion for dorsal root ganglion axons |
| 著者: | Masuda, Tomoyuki
Fukamauchi, Fumihiko
Takeda, Yasuo
Fujisawa, Hajime
Watanabe, Kazutada
Okado, Nobuo
Shiga, Takashi |
| 学内所属: | 解剖学第一講座 |
| 誌名/書名: | Molecular and cellular neurosciences |
| 巻: | 25 |
| 号: | 2 |
| 開始ページ: | 217 |
| 終了ページ: | 227 |
| 発行日: | 2004年2月 |
| 抄録: | During the initial stages of development, the notochord provides repulsive signals for dorsal root ganglion (DRG) axons via semaphorin 3A/neuropilin-1, axonin-1/SC2, and other unknown repulsive molecules. The notochord is known to produce aggrecan, one of the chondroitin sulfate proteoglycans (CSPGs). We report here that adding aggrecan to the culture medium cannot only induce DRG growth cone collapse, but also inhibit DRG axonal growth. Using cocultures composed of tissues derived from chick embryos or neuropilin-1-deficient mice treated with chondroitinase ABC, we show the direct evidence that CSPGs are involved in notochord-derived repulsion for DRG axons. At later developmental stages, CSPGs are involved in perinotochordal sheath-derived axon repulsion, but not in notochord core-derived repulsion. We further demonstrate that TAG-1/axonin-1/SC2 is not involved in mediating repulsive activities by CSPGs, but is required for notochord core-derived axon repulsion. Thus, notochord-derived multiple axon repulsions act in a spatiotemporal-specific manner to shape the initial trajectories of DRG axons. |
| 出版者: | Elsevier |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/759 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/759/1/MolCellNeurosci_25_p217.pdf |
| ISSN: | 1044-7431
1095-9327 |
| DOI: | 10.1016/j.mcn.2003.10.005 |
| PubMed番号: | 15019939 |
| 異版(出版者版等): | https://doi.org/10.1016/j.mcn.2003.10.005 |
| 権利情報: | © 2003. This accepted manuscript version is made available under the CC-BY-NC-ND 4.0 license. http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利情報: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 出現コレクション: | a10 学術雑誌論文等 = Journal Article
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