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Vol.64 (2018) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/707

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Title: Molecular mechanisms and clinical features of heart failure
Authors: Suzuki, Satoshi
Takeishi, Yasuchika
Affiliation: 循環器内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 64
Issue: 3
Start page: 116
End page: 124
Issue Date: 2018
Abstract: Heart failure (HF) is a common disease with high prevalence, mortality in hospitalization and after discharge, readmission rates, and burden on healthcare system. Activation of the inflammatory systems is an important role for HF progression, and pentraxin 3 (PTX3) is one of the inflammatory markers. The plasma PTX3 levels increased with advancing the HF severity, and high levels of plasma PTX3 indicated poor prognosis in HF patients. Moreover, we demonstrated that PTX3 had the crucial role for cardiac remodeling under pressure overload using two different genotypes of mice: PTX3 systemic knockout mice and transgenic mice with cardiac-specific overexpression of PTX3.Diuretics are the essential drug for HF treatment, and we designed multicenter, randomized study for evaluating the efficacy and safety of tolvaptan compared to carperitide. Daily urine volume and serum sodium levels were significantly higher, and cardiovascular events were significantly lower in the tolvaptan group than in the carperitide group. Moreover, we investigated the influence of great earthquake in HF patients, and found out that moving into temporary housing by earthquake might affect the incidence of re-hospitalization due to worsening HF.In this review article, we would introduce our research on HF which has various aspects as described above.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/707
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/707/1/FksmJMedSci_64_p116.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2018-17
PubMed ID: 30344205
Related Page: https://doi.org/10.5387/fms.2018-17
Rights: © 2018 The Fukushima Society of Medical Science
Appears in Collections:Vol.64 (2018)

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FksmJMedSci_64_p116.pdf756.18 kBAdobe PDFDownload

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