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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.64 (2018) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/699
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| Title: | Anti-MDA5 antibody-positive hypomyopathic dermatomyositis complicated with pneumomediastinum |
| Authors: | Yashiro, Makiko
Asano, Tomoyuki
Sato, Shuzo
Kobayashi, Hiroko
Watanabe, Hiroshi
Miyata, Masayuki
Migita, Kiyoshi |
| Affiliation: | リウマチ膠原病内科学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 64 |
| Issue: | 2 |
| Start page: | 89 |
| End page: | 94 |
| Issue Date: | 2018 |
| Abstract: | Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive clinically amyopathic dermatomyositis (CADM) is frequently associated with rapidly progressive interstitial lung disease (RP-ILD) resulting in high mortality. Here we report a 51-year-old Japanese woman with anti-MDA5 antibody-positive hypomyopathic dermatomyositis (DM) who developed RP-ILD. She developed respiratory failure and pneumomediastinum, however her RP-ILD responded favorably to the combined immunosuppressive treatments consisting of steroids, intravenous cyclophosphamide and tacrolimus. She was complicated with severe infections, which were successfully managed by combined modality therapy including artificial ventilation and antibiotics in addition to immunosuppressive treatments in parallel to the decline of anti-MDA5 antibody titer (>150 Index to 75 Index). She was discharged after 6 months of treatment without any respiratory sequelae. Hypomyopathic DM patients with high titers of anti-MDA5 antibody should be treated with aggressive immunosuppressive therapies and closely monitored to prevent various infections. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/699 |
| Full text URL: | https://ir.fmu.ac.jp/dspace/bitstream/123456789/699/1/FksmJMedSci_64_p89.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2018-01 |
| PubMed ID: | 30158335 |
| Related Page: | https://doi.org/10.5387/fms.2018-01 |
| Rights: | © 2018 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.64 (2018)
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