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Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/699

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Title: Anti-MDA5 antibody-positive hypomyopathic dermatomyositis complicated with pneumomediastinum
Authors: Yashiro, Makiko
Asano, Tomoyuki
Sato, Shuzo
Kobayashi, Hiroko
Watanabe, Hiroshi
Miyata, Masayuki
Migita, Kiyoshi
Affiliation: リウマチ膠原病内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 64
Issue: 2
Start page: 89
End page: 94
Issue Date: 2018
Abstract: Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive clinically amyopathic dermatomyositis (CADM) is frequently associated with rapidly progressive interstitial lung disease (RP-ILD) resulting in high mortality. Here we report a 51-year-old Japanese woman with anti-MDA5 antibody-positive hypomyopathic dermatomyositis (DM) who developed RP-ILD. She developed respiratory failure and pneumomediastinum, however her RP-ILD responded favorably to the combined immunosuppressive treatments consisting of steroids, intravenous cyclophosphamide and tacrolimus. She was complicated with severe infections, which were successfully managed by combined modality therapy including artificial ventilation and antibiotics in addition to immunosuppressive treatments in parallel to the decline of anti-MDA5 antibody titer (>150 Index to 75 Index). She was discharged after 6 months of treatment without any respiratory sequelae. Hypomyopathic DM patients with high titers of anti-MDA5 antibody should be treated with aggressive immunosuppressive therapies and closely monitored to prevent various infections.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/699
Full text URL: https://ir.fmu.ac.jp/dspace/bitstream/123456789/699/1/FksmJMedSci_64_p89.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2018-01
PubMed ID: 30158335
Related Page: https://doi.org/10.5387/fms.2018-01
Rights: © 2018 The Fukushima Society of Medical Science
Appears in Collections:Vol.64 (2018)

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FksmJMedSci_64_p89.pdf2.03 MBAdobe PDFDownload

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