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Vol.64 (2018) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/698

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Title: Methotrexate-associated lymphoproliferative disorder complicated by severe acute respiratory failure and ileal perforation:a case report
Authors: Suzuki, Eiji
Kanno, Takashi
Kimura, Satoru
Irie, Takumi
Odajima, Hajime
Migita, Kiyoshi
Affiliation: リウマチ膠原病内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 64
Issue: 2
Start page: 82
End page: 88
Issue Date: 2018
Abstract: Lymphoproliferative disorder (LPD) is a potentially severe adverse effect of methotrexate (MTX) administration in patients with rheumatoid arthritis (RA). We report a case of MTX-associated LPD (MTX-LPD) in a patient with RA who developed severe pulmonary failure complicated by perforation of the terminal ileum. A 61-year-old woman with RA receiving MTX complained of dyspnea and abdominal pain. She was diagnosed with intestinal perforation and peritonitis, and underwent immediate abdominal surgery. Pathological examinations of the specimen obtained from the resected ileum and a bone marrow aspirate revealed diffuse large B-cell lymphoma. Steroid therapy failed to improve her respiratory failure, but her condition improved after abdominal surgery and suspension of MTX. MTX-LPD can result in multiple life-threatening conditions; however, the symptoms are highly variable. RA patients receiving MTX should thus be monitored carefully, and MTX administration should be stopped immediately on suspicion of MTX-LPD.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/698
Full text URL: https://ir.fmu.ac.jp/dspace/bitstream/123456789/698/1/FksmJMedSci_64_p82.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2017-23
PubMed ID: 29925726
Related Page: https://doi.org/10.5387/fms.2017-23
Rights: © 2018 The Fukushima Society of Medical Science
Appears in Collections:Vol.64 (2018)

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FksmJMedSci_64_p82.pdf1.11 MBAdobe PDFDownload

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