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Vol.64 (2018) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/696

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Title: Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells
Authors: Shimura, Tatsuo
Shibata, Masahiko
Gonda, Kenji
Hayase, Suguru
Sakamoto, Wataru
Okayama, Hirokazu
Fujita, Shotaro
Saito, Motonobu
Momma, Tomoyuki
Ohki, Shinji
Kono, Koji
Affiliation: プログレッシブDOHaD研究講座
先端癌免疫治療研究講座
臨床腫瘍センター
消化管外科学講座
Source title: Fukushima Journal of Medical Science
Volume: 64
Issue: 2
Start page: 64
End page: 72
Issue Date: 2018
Abstract: Aims: We aimed to investigate the relationship of colorectal cancer prognosis and inflammatory parameters, including neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR), with reference to circulating myeloid-derived suppressor cells (MDSCs) in the current study. Patients and Methods: Thirty-five patients who underwent curative-intent surgery were enrolled. A receiver-operating characteristic curve (ROC) was used to assess the usefulness of candidates for prognostic factors. Recurrence-free survival (RFS) was calculated using the Kaplan-Meier method, and the candidates for prognostic factors were assessed by a Cox proportional hazard model. Results: ROC curve analyses determined cutoff values for NLR and LMR as 2.9 and 2.4, respectively. The percentage of MDSCs in patients with LMR ≤ 2.4 was statistically higher than in those with LMR > 2.4 (p = 0.012). The patients with LMR ≤ 2.4 exhibited a statistically lower RFS than those with LMR > 2.4 (p = 0.008). These results were also observed in patients with stage II + III disease. LMR was an independent prognostic factor of RFS in colorectal cancer patients (hazard ratio: 7.757, 95% confidence interval: 1.462-41.152, p = 0.016). Conclusion: Lower LMR was associated with poor prognosis in colorectal cancer patients; whereas, higher circulating MDSCs were observed in patients with lower LMR.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/696
Full text URL: https://ir.fmu.ac.jp/dspace/bitstream/123456789/696/1/FksmJMedSci_64_p64.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.2018-10
PubMed ID: 30012939
Related Page: https://doi.org/10.5387/fms.2018-10
Rights: © 2018 The Fukushima Society of Medical Science
Appears in Collections:Vol.64 (2018)

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