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Fukushima Journal of Medical Science >
Vol.64 (2018) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/695

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Title: Feasibility of skin acetone analysis in patients with cardiovascular diseases
Authors: Yokokawa, Tetsuro
Sato, Takamasa
Suzuki, Satoshi
Oikawa, Masayoshi
Yoshihisa, Akiomi
Kobayashi, Atsushi
Yamaki, Takayoshi
Kunii, Hiroyuki
Nakazato, Kazuhiko
Ishida, Takafumi
Takeishi, Yasuchika
Affiliation: 循環器内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 64
Issue: 2
Start page: 60
End page: 63
Issue Date: 2018
Abstract: Background: Breath acetone is reported to be a noninvasive biomarker for heart failure. However, the measurement of this metabolite requires expertize and is not standardized yet. Acetone is also released from the skin; thus, measuring acetone as a skin gas may be easier than breath analysis. Methods: We analyzed skin acetone collected from 41 hospitalized patients with cardiovascular diseases. Passive samplers were used to measure skin acetone emission. Passive sampler was softly fixed on the surface of forearm skin for 10 hour at night. Results: Skin acetone emission ranged from 0.00 to 2.70 ng/cm2/h, and was significantly correlated with blood ketone bodies (r = 0.377, p = 0.017). Conclusions: This is the first study to analyze skin gas in patients with cardiovascular diseases. Skin acetone emission was found to reflect blood ketone bodies. It is feasible to measure skin acetone emission for reflecting blood ketone bodies in patients with cardiovascular diseases.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/695
Full text URL: https://ir.fmu.ac.jp/dspace/bitstream/123456789/695/1/FksmJMedSci_64_p60.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.2018-03
PubMed ID: 30012937
Related Page: https://doi.org/10.5387/fms.2018-03
Rights: © 2018 The Fukushima Society of Medical Science
Appears in Collections:Vol.64 (2018)

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FksmJMedSci_64_p60.pdf231.87 kBAdobe PDFDownload

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