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Vol.64 (2018) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/693

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Title: Immunotherapy for esophageal squamous cell carcinoma: a review
Authors: Mimura, Kosaku
Yamada, Leo
Ujiie, Daisuke
Hayase, Suguru
Tada, Takeshi
Hanayama, Hiroyuki
Aung Kyi Thar Min
Shibata, Masahiko
Momma, Tomoyuki
Saze, Zenichiro
Ohki, Shinji
Kono, Koji
Affiliation: 消化管外科学講座
Source title: Fukushima Journal of Medical Science
Volume: 64
Issue: 2
Start page: 46
End page: 53
Issue Date: 2018
Abstract: Cancer vaccines and immune checkpoint inhibitors (ICI) have recently been employed as immunotherapies for esophageal squamous cell carcinoma (ESCC). Cancer vaccines for ESCC have yielded several promising results from investigator-initiated phase I and II clinical trials. Furthermore, a Randomized Controlled Trial as an adjuvant setting after curative surgery is in progress in Japan. On the other hand, ICI, anti-CTLA-4 mAb and anti-PD-1 mAb, have demonstrated tumor shrinkage and improved overall survival in patients with multiple cancer types. For ESCC, several clinical trials using anti-PD-1/anti-PD-L1 mAb are underway with several recent promising results. In this review, cancer vaccines and ICI are discussed as novel therapeutic strategies for ESCC.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/693
Full text URL: https://ir.fmu.ac.jp/dspace/bitstream/123456789/693/1/FksmJMedSci_64_p46.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2018-09
PubMed ID: 30058598
Related Page: https://doi.org/10.5387/fms.2018-09
Rights: © 2018 The Fukushima Society of Medical Science
Appears in Collections:Vol.64 (2018)

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FksmJMedSci_64_p46.pdf1.36 MBAdobe PDFDownload

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