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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.64 (2018) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/673
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| タイトル: | Targeted therapy according to next generation sequencing-based panel sequencing |
| 著者: | Saito, Motonobu
Momma, Tomoyuki
Kono, Koji |
| 学内所属: | 消化管外科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 64 |
| 号: | 1 |
| 開始ページ: | 9 |
| 終了ページ: | 14 |
| 発行日: | 2018年 |
| 抄録: | Targeted therapy against actionable gene mutations shows a significantly higher response rate as well as longer survival compared to conventional chemotherapy, and has become a standard therapy for many cancers. Recent progress in next-generation sequencing (NGS) has enabled to identify huge number of genetic aberrations. Based on sequencing results, patients recommend to undergo targeted therapy or immunotherapy. In cases where there are no available approved drugs for the genetic mutations detected in the patients, it is recommended to be facilitate the registration for the clinical trials. For that purpose, a NGS-based sequencing panel that can simultaneously target multiple genes in a single investigation has been used in daily clinical practice. To date, various types of sequencing panels have been developed to investigate genetic aberrations with tumor somatic genome variants (gain-of-function or loss-of-function mutations, high-level copy number alterations, and gene fusions) through comprehensive bioinformatics. Because sequencing panels are efficient and cost-effective, they are quickly being adopted outside the lab, in hospitals and clinics, in order to identify personal targeted therapy for individual cancer patients. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/673 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/673/1/FksmJMedSci_64_p9.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2018-02 |
| PubMed番号: | 29628467 |
| 関連ページ: | https://doi.org/10.5387/fms.2018-02 |
| 権利情報: | © 2018 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.64 (2018)
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