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Vol.64 (2018) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/673

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Title: Targeted therapy according to next generation sequencing-based panel sequencing
Authors: Saito, Motonobu
Momma, Tomoyuki
Kono, Koji
Affiliation: 消化管外科学講座
Source title: Fukushima Journal of Medical Science
Volume: 64
Issue: 1
Start page: 9
End page: 14
Issue Date: 2018
Abstract: Targeted therapy against actionable gene mutations shows a significantly higher response rate as well as longer survival compared to conventional chemotherapy, and has become a standard therapy for many cancers. Recent progress in next-generation sequencing (NGS) has enabled to identify huge number of genetic aberrations. Based on sequencing results, patients recommend to undergo targeted therapy or immunotherapy. In cases where there are no available approved drugs for the genetic mutations detected in the patients, it is recommended to be facilitate the registration for the clinical trials. For that purpose, a NGS-based sequencing panel that can simultaneously target multiple genes in a single investigation has been used in daily clinical practice. To date, various types of sequencing panels have been developed to investigate genetic aberrations with tumor somatic genome variants (gain-of-function or loss-of-function mutations, high-level copy number alterations, and gene fusions) through comprehensive bioinformatics. Because sequencing panels are efficient and cost-effective, they are quickly being adopted outside the lab, in hospitals and clinics, in order to identify personal targeted therapy for individual cancer patients.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/673
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/673/1/FksmJMedSci_64_p9.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2018-02
PubMed ID: 29628467
Related Page: https://doi.org/10.5387/fms.2018-02
Rights: © 2018 The Fukushima Society of Medical Science
Appears in Collections:Vol.64 (2018)

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