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Vol.64 (2018) >

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Title: Induction of anti-PF4/heparin antibodies after arthroplasty for rheumatic diseases
Authors: Migita, Kiyoshi
Asano, Tomoyuki
Sato, Shuzo
Motokawa, Satoru
Affiliation: リウマチ膠原病内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 64
Issue: 1
Start page: 1
End page: 8
Issue Date: 2018
Abstract: Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. These pathogenic antibodies against PF4/heparin bind and activate cellular FcγRIIa on platelets to induce a hypercoagulable state culminating in thrombosis. Recent studies indicate several conditions, including joint surgery, induce spontaneous HIT, which can occur without exposure to heparin. To determine the real-world evidences concerning the incidences of venous thromboembolism (VTE) after total joint arthroplasty for rheumatic disease, we conducted a multicenter cohort study (J-PSVT) designed to document the VTE and seroconversion rates of anti-PF4/heparin antibody in 34 Japanese National hospital organization (NHO) hospitals. J-PSVT indicated that prophylaxis with fondaparinux, not enoxaparin, reduces the risk of deep vein thrombosis in patients undergoing arthroplasty. Multivariate analysis revealed that dynamic mechanical thromboprophylaxis (intermittent plantar device) was an independent risk factor for seroconversion of anti-PF4/heparin antibodies, which was also confirmed by propensity-score matching. Seroconversion rates of anti-PF4/heparin antibodies were significantly reduced in rheumatoid arthritis (RA) patients compared with osteoarthritis (OA) patients, which may link with the findings that IgG fractions isolated from RA patients not OA patients contained PF4. Our study indicated that a unique profile of anti-PF4/heparin antibodies is induced by arthroplasty for rheumatic diseases.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/672
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/672/1/FksmJMedSci_64_p1.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2018-06
PubMed ID: 29628468
Related Page: https://doi.org/10.5387/fms.2018-06
Rights: © 2018 The Fukushima Society of Medical Science
Appears in Collections:Vol.64 (2018)

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