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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.63 (2017) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/670
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| Title: | Two cases of liver cirrhosis treated with lusutrombopag before partial splenic embolization |
| Authors: | Fujita, Masashi
Abe, Kazumichi
Hayashi, Manabu
Okai, Ken
Takahashi, Atsushi
Ohira, Hiromasa |
| Affiliation: | 消化器内科学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 63 |
| Issue: | 3 |
| Start page: | 165 |
| End page: | 171 |
| Issue Date: | 2017 |
| Abstract: | Lusutrombopag, a small molecule thrombopoietin receptor agonist, has been approved for the treatment of chronic liver disease-associated thrombocytopenia due to hypersplenism in patients scheduled to undergo elective invasive procedures in Japan. We performed partial splenic embolization (PSE) after administration of lusutrombopag in two patients with thrombocytopenia due to cirrhosis. Case 1 involved a 50-year-old man who developed cirrhosis due to hepatitis B virus (HBV) infection and alcohol consumption. Case 2 involved a 30-year-old woman who developed cirrhosis due to HBV infection only. Lusutrombopag administration led to an increase in platelet count in both patients, and PSE was performed safely. However, in Case 2, the patient developed disseminated intravascular coagulation. Further study with a larger population is required to investigate the indications for and risks of the use of lusutrombopag. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/670 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/670/1/FksmJMedSci_63_p165.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2017-07 |
| PubMed ID: | 29142151 |
| Related Page: | https://doi.org/10.5387/fms.2017-07 |
| Rights: | © 2017 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.63 (2017)
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