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Vol.63 (2017) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/667

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Title: TBX19 is overexpressed in colorectal cancer and associated with lymph node metastasis
Authors: Ando, Jin
Saito, Motonobu
Imai, Jun-Ichi
Ito, Emi
Yanagisawa, Yuka
Honma, Reiko
Saito, Katsuharu
Tachibana, Kazunoshin
Momma, Tomoyuki
Ohki, Shinji
Ohtake, Tohru
Watanabe, Shinya
Waguri, Satoshi
Kono, Koji
Takenoshita, Seiichi
Affiliation: 消化管外科学講座
Source title: Fukushima Journal of Medical Science
Volume: 63
Issue: 3
Start page: 141
End page: 151
Issue Date: 2017
Abstract: The T-box 19 (TBX19) gene encodes a transcription factor characterized by a highly conserved DNA-binding motif (T-box). Recent studies have revealed that TBX19 has been identified as one of the genes activated by KRAS mutations, and is upregulated in colon adenoma. These results indicate that TBX19 may work as an oncogene in colorectal cancer (CRC). However, the expression and role of TBX19 have yet to be investigated. Here, we investigated TBX19 mRNA and protein expressions in colon cancer cells or surgically resected CRC. We found that TBX19 mRNA expression was significantly increased in tumorous tissues compared to that in non-tumorous tissues, and increased TBX19 mRNA expression was associated with positive lymph node metastasis in our cohort. The expression of TBX19 mRNA was not correlated with that of TBX19 protein in tissue sample taken from the CRC patients. Moreover, TBX19 showed positive staining even in the normal colonic tissues and the adjacent non-tumorous tissues. These results suggest that the expression of TBX19 protein is not correlated with the expression of TBX19 mRNA. In addition, our results promote further investigations into the impact of TBX19 upregulation on colorectal carcinogenesis, as well as the underlying mechanisms.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/667
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/667/1/FksmJMedSci_63_p141.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2017-08
PubMed ID: 29199261
Related Page: https://doi.org/10.5387/fms.2017-08
Rights: © 2017 The Fukushima Society of Medical Science
Appears in Collections:Vol.63 (2017)

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