|
福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.63 (2017) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/665
|
| タイトル: | Neutralizing epitopes of RSV and palivizumab resistance in Japan |
| 著者: | Hashimoto, Koichi
Hosoya, Mitsuaki |
| 学内所属: | 小児科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 63 |
| 号: | 3 |
| 開始ページ: | 127 |
| 終了ページ: | 134 |
| 発行日: | 2017年 |
| 抄録: | Respiratory Syncytial Virus (RSV) is one of the most important viral pathogen related to acute lower respiratory infection in young children. The virus surface envelope contains the G, F, and SH proteins as spike proteins. The F protein is considered to be a major antigenic target for the neutralizing (NT) epitope as only the F protein is essential for cell infection among the three viral envelope proteins, and it is more highly conserved than the G protein. Recently, four antigenic targets related to NT activity have been reported;site I, site II, site IV, and site zero (0). Site II is the target for palivizumab used throughout the world to suppress severe RSV infection as passive immunity in high-risk children since 1998. Under the recent conditions in which indications for palivizumab administered subjects are being expanded, palivizumab-resistant mutations have been confirmed overseas in children with RSV infection, although they remain infrequent. Therefore, continuous genetic analysis of the palivizumab-binding region of the F protein is necessary. In addition, as vaccine development progresses, RSV infection control is expected to improve greatly over the next decade. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/665 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/665/1/FksmJMedSci_63_p127.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2017-09 |
| PubMed番号: | 28867684 |
| 関連ページ: | https://doi.org/10.5387/fms.2017-09 |
| 権利情報: | © 2017 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.63 (2017)
|
このリポジトリに保管されているアイテムは、他に指定されている場合を除き、著作権により保護されています。
|
