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Title: Apparent diffusion coefficient on magnetic resonance imaging (MRI) in bladder cancer: relations with recurrence/progression risk
Authors: Kikuchi, Ken
Shigihara, Takeshi
Hashimoto, Yuko
Miyajima, Masayuki
Haga, Nobuhiro
Kojima, Yoshiyuki
Shishido, Fumio
Affiliation: 放射線医学講座
Source title: Fukushima Journal of Medical Science
Volume: 63
Issue: 2
Start page: 90
End page: 99
Issue Date: 2017
Abstract: AIMS: To evaluate the relationship between the apparent diffusion coefficient (ADC) value for bladder cancer and the recurrence/progression risk of post-transurethral resection (TUR). METHODS: Forty-one patients with initial and non-muscle-invasive bladder cancer underwent MRI from 2009 to 2012. Two radiologists measured ADC values. A pathologist calculated the recurrence/progression scores, and risk was classified based on the scores. Pearson's correlation was used to analyze the correlations of ADC value with each score and with each risk group, and the optimal cut-off value was established based on receiver operating characteristic (ROC) curve analysis. Furthermore, the relationship between actual recurrence / progression of cases and ADC values was examined by Unpaird U test. RESULTS: There were significant correlations between ADC value and the recurrence score as well as the progression score (P<0.01, P<0.01, respectively). There were also significant correlations between ADC value and the recurrence risk group as well as progression risk group (P=0.042, P<0.01, respectively). The ADC cut-off value on ROC analysis was 1.365 (sensitivity 100%; specificity 97.4%) for the low and intermediate recurrence risk groups, 1.024 (sensitivity 47.4%; specificity 100%) for the intermediate and high recurrence risk groups, 1.252 (sensitivity 83.3%; specificity 81.3%) for the low and intermediate progression risk groups, and 0.955 (sensitivity 87.5%; specificity 63.2%) between the intermediate and high progression risk groups. The difference between the ADC values of the recurrence and nonrecurrence group in Unpaired t test was significant (P<0.05). CONCLUSION: ADC on MRI in bladder cancer could potentially be useful, non-invasive measurement for estimating the risks of recurrence and progression.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/645
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/645/1/FksmJMedSci_63_p90.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2017-05
PubMed ID: 28680010
Related Page: http://doi.org/10.5387/fms.2017-05
Rights: © 2017 The Fukushima Society of Medical Science
Appears in Collections:Vol.63 (2017)

Files in This Item:

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FksmJMedSci_63_p90.pdf957.69 kBAdobe PDFDownload

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