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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.62 (2016) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/521
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| Title: | Clinicopathological significance of lymphangiogenesis detected by immunohistochemistry using D2-40 monoclonal antibody in breast cancer |
| Authors: | Abe, Noriko
Ohtake, Tohru
Saito, Katsuharu
Kumamoto, Kensuke
Sugino, Takashi
Takenoshita, Seiichi |
| Affiliation: | 器官制御外科学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 62 |
| Issue: | 1 |
| Start page: | 57 |
| End page: | 63 |
| Issue Date: | 2016 |
| Abstract: | To elucidate the association between the lymphangiogenesis and clinicopathological factors including the survival in breast cancer, 91 Japanese patients with breast cancer were investigated. The lymphangiogenesis was evaluated by the count of lymph vessel density (LVD) with immunohistochemical method using D2-40 monoclonal antibody, a specific marker for lymphatic endothelial cells.D2-40-positive lymph vessels were detected in 87 of 91 cases, and were mainly distributed in the peritumoral lesions or around the tumor edge. There was a significant difference in disease-free survival (DFS) and overall survival (OS) between patients with high LVD and with low LVD (p=0.02, 0.01, respectively, log-rank test). In addition, LVD significantly correlated with the following clinicopathological factors: menopausal status (p<0.01), tumor size (p<0.01), lymph-node status (p=0.01) lymphatic vessel invasion (LVI) (p<0.01), blood vessel invasion (BVI) (p=0.03) and estrogen receptor status (ER) (p=0.02).Those data suggest that D2-40 monoclonal antibody is a useful marker for evaluating the LVD and its evaluation is helpful to predict the survival in breast cancer. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/521 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/521/1/FksmJMedSci_62_p57.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2015-10 |
| PubMed ID: | 27210308 |
| Related Page: | http://doi.org/10.5387/fms.2015-10 |
| Rights: | © 2016 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.62 (2016)
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