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福島医学会 = The Fukushima Society of Medical Science >
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Vol.62 (2016) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/521

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Title: Clinicopathological significance of lymphangiogenesis detected by immunohistochemistry using D2-40 monoclonal antibody in breast cancer
Authors: Abe, Noriko
Ohtake, Tohru
Saito, Katsuharu
Kumamoto, Kensuke
Sugino, Takashi
Takenoshita, Seiichi
Affiliation: 器官制御外科学講座
Source title: Fukushima Journal of Medical Science
Volume: 62
Issue: 1
Start page: 57
End page: 63
Issue Date: 2016
Abstract: To elucidate the association between the lymphangiogenesis and clinicopathological factors including the survival in breast cancer, 91 Japanese patients with breast cancer were investigated. The lymphangiogenesis was evaluated by the count of lymph vessel density (LVD) with immunohistochemical method using D2-40 monoclonal antibody, a specific marker for lymphatic endothelial cells.D2-40-positive lymph vessels were detected in 87 of 91 cases, and were mainly distributed in the peritumoral lesions or around the tumor edge. There was a significant difference in disease-free survival (DFS) and overall survival (OS) between patients with high LVD and with low LVD (p=0.02, 0.01, respectively, log-rank test). In addition, LVD significantly correlated with the following clinicopathological factors: menopausal status (p<0.01), tumor size (p<0.01), lymph-node status (p=0.01) lymphatic vessel invasion (LVI) (p<0.01), blood vessel invasion (BVI) (p=0.03) and estrogen receptor status (ER) (p=0.02).Those data suggest that D2-40 monoclonal antibody is a useful marker for evaluating the LVD and its evaluation is helpful to predict the survival in breast cancer.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/521
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/521/1/FksmJMedSci_62_p57.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.2015-10
PubMed ID: 27210308
Related Page: http://doi.org/10.5387/fms.2015-10
Rights: © 2016 The Fukushima Society of Medical Science
Appears in Collections:Vol.62 (2016)

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