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Vol.62 (2016) >

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Title: Gastric endoscopic submucosal dissection using sodium carboxymethylcellulose as a new injection substance
Authors: Hikichi, Takuto
Yamasaki, Masahiro
Watanabe, Ko
Nakamura, Jun
Sato, Masaki
Takagi, Tadayuki
Suzuki, Rei
Sugimoto, Mitsuru
Kikuchi, Hitomi
Konno, Naoki
Waragai, Yuichi
Asama, Hiroyuki
Takasumi, Mika
Ejiri, Yutaka
Watanabe, Hiroshi
Ohira, Hiromasa
Obara, Katsutoshi
Affiliation: 内視鏡診療部
消化器・リウマチ膠原病内科学講座
消化器内視鏡先端医療支援講座
Source title: Fukushima Journal of Medical Science
Volume: 62
Issue: 1
Start page: 43
End page: 50
Issue Date: 2016
Abstract: AIM: To investigate the feasibility of endoscopic submucosal dissection (ESD) using sodium carboxymethylcellulose (SCMC) for gastric cancer. METHODS: During October 2011 through April 2013, 98 lesions from 98 patients who underwent ESD using SCMC (ESD-SCMC) for early gastric cancer were enrolled in this study. Two endoscopists, who had each performed fewer than 30 ESD procedures (less-experienced ESD physicians), performed ESD-SCMC under the supervision of two experts. The primary outcome was the en bloc resection rate. Secondary outcomes included the complete resection rate, the procedural time, the bleeding rate after SCMC injection, and complications. Patient characteristics, time necessary for hemostasis after SCMC injection, rate of treatment completion by less-experienced ESD physicians alone, and the effects of SCMC during ESD and on resected specimens were also evaluated. RESULTS: The en bloc resection rate was 100%. Among these resections, 87.8% of the cases were completed by a less-experienced ESD physician alone. The complete resection rate was 98.0%. The mean total procedural time was 75.4 min. The mean incidence of intraoperative bleeding following SCMC local injection was 1.7 times. No bleeding was observed after SCMC injection in 29.6% of cases (29/98). Five complications occurred: one case of microperforation (1.0%) and four cases of postoperative bleeding (4.0%). SCMC remained in the submucosa. The submucosa was readily manipulated when the deep submucosa was dissected, even after placing the specimen on a slide. CONCLUSION: ESD-SCMC is feasible for the resection of early gastric cancer.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/519
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/519/1/FksmJMedSci_62_p43.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.2015-27
PubMed ID: 27020144
Related Page: http://doi.org/10.5387/fms.2015-27
Rights: © 2016 The Fukushima Society of Medical Science
Appears in Collections:Vol.62 (2016)

Files in This Item:

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FksmJMedSci_62_p43.pdf3.13 MBAdobe PDFDownload

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