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Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/495

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Title: Clinical application of L-menthol in the upper gastrointestinal endoscopic procedure
Authors: Kikuchi, Hitomi
Hikichi, Takuto
Takagi, Tadayuki
Suzuki, Rei
Watanabe, Ko
Nakamura, Jun
Sugimoto, Mitsuru
Waragai, Yuichi
Konno, Naoki
Asama, Hiroyuki
Takasumi, Mika
Watanabe, Hiroshi
Obara, Katsutoshi
Ohira, Hiromasa
Affiliation: 消化器・リウマチ膠原病内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 61
Issue: 2
Start page: 160
End page: 166
Issue Date: 2015
Abstract: Aim: Peppermint oil, which suppresses gastric peristalsis during esophagogastroduodenoscopy (EGD), is effective for determining the margin of a gastric tumor. This study was conducted to evaluate the utility of an L-menthol preparation for suppressing gastric peristalsis and for diagnosing gastric tumors. Methods: The study examined 124 patients who underwent EGD between January and April 2012. After 20 mL of 0.8% L-menthol was sprayed directly onto the mucosal surface of the gastric antrum, the degree of peristalsis suppression in the antrum was evaluated. The effectiveness of L-menthol for identifying new gastric tumors and determining tumor margins was also evaluated. Results: Gastric peristalsis was suppressed in 88.5% (69/78) of patients, with complete suppression of peristalsis achieved in 78.2%. L-menthol exerted a higher peristalsis-suppressive effect in patients with endoscopic gastric mucosal atrophy (93.3%, 56/60) than in patients without atrophy (72.2%, 13/18) (p = .014). L-menthol application caused the detection of new gastric tumors in 1.6% (2/124) of patients and clarification of the margin of three lesions (in 3 patients) identified as having an unclear margin before L-menthol application. Conclusion: These results suggest that L-menthol is effective for suppressing gastric peristalsis during EGD and suggest that it is useful for identifying gastric tumors and for determining tumor margins.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/495
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/495/1/FksmJMedSci_61_p160.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2015-18
PubMed ID: 26632191
Related Page: http://doi.org/10.5387/fms.2015-18
Rights: © 2015 The Fukushima Society of Medical Science
Appears in Collections:Vol.61 (2015)

Files in This Item:

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FksmJMedSci_61_p160.pdf1.44 MBAdobe PDFDownload

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