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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.61 (2015) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/493
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| タイトル: | Down's syndrome with neonatal alloimmune thrombocytopenia due to HLA-A2 antibody |
| 著者: | Nakamura, Toshihiko
Nomura, Tomoaki
Kamohara, Takashi
Takahashi, Hidehiro
Hatanaka, Daisuke
Kusakari, Michiko
Nakamura, Mari
Kawabata, Kinuyo
Ohto, Hitoshi |
| 学内所属: | 輸血・移植免疫学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 61 |
| 号: | 2 |
| 開始ページ: | 149 |
| 終了ページ: | 154 |
| 発行日: | 2015年 |
| 抄録: | Anti-HLA antibodies reportedly exist in the one third of pregnant women. But few occurrences of neonatal alloimmune thrombocytopenia (NAIT) caused by anti-HLA antibodies have been reported. Here a male baby, who was admitted for low birth weight with Down syndrome (DS), was suffered from thrombocytopenia without transient myeloproliferative disorder (TMD). Positive reactions of HLA-specific antibodies were detected in maternal serum. Cross-matching tests between maternal serum and paternal platelets and lymphocytes were strongly positive. It is most conceivable that the previous pregnancy of the mother induced the production of anti-HLA-A2 antibody, which crossed the placenta and subsequently caused an NAIT in the case presented. This is the first case of DS with NAIT due to anti-HLA antibodies. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/493 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/493/1/FksmJMedSci_61_p149.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2015-19 |
| PubMed番号: | 26632192 |
| 関連ページ: | http://doi.org/10.5387/fms.2015-19 |
| 権利情報: | © 2015 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.61 (2015)
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