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Vol.61 (2015) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/493

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Title: Down's syndrome with neonatal alloimmune thrombocytopenia due to HLA-A2 antibody
Authors: Nakamura, Toshihiko
Nomura, Tomoaki
Kamohara, Takashi
Takahashi, Hidehiro
Hatanaka, Daisuke
Kusakari, Michiko
Nakamura, Mari
Kawabata, Kinuyo
Ohto, Hitoshi
Affiliation: 輸血・移植免疫学講座
Source title: Fukushima Journal of Medical Science
Volume: 61
Issue: 2
Start page: 149
End page: 154
Issue Date: 2015
Abstract: Anti-HLA antibodies reportedly exist in the one third of pregnant women. But few occurrences of neonatal alloimmune thrombocytopenia (NAIT) caused by anti-HLA antibodies have been reported. Here a male baby, who was admitted for low birth weight with Down syndrome (DS), was suffered from thrombocytopenia without transient myeloproliferative disorder (TMD). Positive reactions of HLA-specific antibodies were detected in maternal serum. Cross-matching tests between maternal serum and paternal platelets and lymphocytes were strongly positive. It is most conceivable that the previous pregnancy of the mother induced the production of anti-HLA-A2 antibody, which crossed the placenta and subsequently caused an NAIT in the case presented. This is the first case of DS with NAIT due to anti-HLA antibodies.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/493
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/493/1/FksmJMedSci_61_p149.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2015-19
PubMed ID: 26632192
Related Page: http://doi.org/10.5387/fms.2015-19
Rights: © 2015 The Fukushima Society of Medical Science
Appears in Collections:Vol.61 (2015)

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