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Vol.61 (2015) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/462

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Title: Brain hypothermia therapy for neonatal hypoxic-ischemic encephalopathy with a severely elevated serum creatine kinase level
Authors: Kinoshita, Hidetoshi
Imamura, Takashi
Maeda, Hajime
Shibukawa, Yasuko
Fukuda, Yutaka
Kin, Shogo
Ariga, Hiromichi
Nagasawa, Katsutoshi
Source title: Fukushima Journal of Medical Science
Volume: 61
Issue: 1
Start page: 54
End page: 57
Issue Date: 2015
Abstract: Several studies have shown that brain hypothermia therapy (BHT) after neonatal hypoxic-ischemic encephalopathy (HIE) can improve neurodevelopmental outcomes. However, there have been no reports of the neurodevelopmental outcomes for the infant with a serum creatine kinase (CK) level above 20,000 IU/L in association with neonatal HIE. We report a female infant with a very high serum CK level (26,428 IU/L) associated with neonatal asphyxia. We diagnosed this infant with moderate HIE, and BHT was achieved by head cooling within 6 hours after birth to an esophageal temperature of 34.5°C. There were no significant adverse events during BHT, and the CK level spontaneously decreased. Although we report only the short-term outcomes for this case, she presents neurodevelopmental delays at the age of 18 months. It may be correlated between high serum CK level and long-term neurodevelopmental delays. Abbreviations: CK, creatine kinase; HIE, hypoxic-ischemic encephalopathy; BHT, brain hypothermia therapy; NRFS, non-reassuring fetal status; CK-MB, creatine kinase-myocardial band; MRI, magnetic resonance imaging; CK-BB, creatine kinase-brain band.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/462
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/462/1/FksmJMedSci_61_p54.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.2014-30
PubMed ID: 25946908
Related Page: http://doi.org/10.5387/fms.2014-30
Rights: © 2015 The Fukushima Society of Medical Science
Appears in Collections:Vol.61 (2015)

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