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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.61 (2015) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/461
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| Title: | The inhibitory effect of paclitaxel on (KV2.1) K^+ current in H9c2 cells |
| Authors: | Kitamura, Naoko
Sakamoto, Kazuho
Ono, Tomoyuki
Kimura, Junko |
| Affiliation: | 薬理学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 61 |
| Issue: | 1 |
| Start page: | 47 |
| End page: | 53 |
| Issue Date: | 2015 |
| Abstract: | Using the whole-cell voltage clamp technique, we investigated the effect of paclitaxel, an anticancer agent which promotes microtubule formation, on K^+ current in H9c2 cells originated from rat embryonic cardiac myocytes. Paclitaxel inhibited Kv2.1 voltage-dependent K^+ current (IKur) with ultra-rapidly activating and slowly inactivating kinetics in a concentration-dependent manner. The inhibitory effect of paclitaxel on IKur was time-dependent and more marked at 200 ms after the onset than at the beginning of the depolarizing pulse. The IC50 value of paclitaxel was 1.1 µM at 200 ms. The time-dependent inhibition suggests that paclitaxel might be an open channel blocker of Kv2.1. This inhibition of Kv2.1 may be involved in the adverse effects of paclitaxel on cardiac and neuronal cells. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/461 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/461/1/FksmJMedSci_61_p47.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2014-34 |
| PubMed ID: | 25994081 |
| Related Page: | http://doi.org/10.5387/fms.2014-34 |
| Rights: | © 2015 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.61 (2015)
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