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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.61 (2015) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/458
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| タイトル: | Validation of therapeutic response assessment by bone scintigraphy in patients with bone-only metastatic breast cancers during zoledronic acid treatment: comparison with computed tomography assessment |
| 著者: | Ishii, Shirou
Kikuchi, Ken
Miyajima, Masayuki
Sakuma, Kotaro
Shishido, Fumio |
| 学内所属: | 放射線医学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 61 |
| 号: | 1 |
| 開始ページ: | 23 |
| 終了ページ: | 31 |
| 発行日: | 2015年 |
| 抄録: | Purpose: To validate the use of bone scintigraphy (BS) versus computed tomography (CT) for therapeutic monitoring in patients during treatment with zoledronic acid. Materials and Methods: Eleven patients with bone-only metastatic disease and being treated with zoledronic acid were included. The effects of therapies including chemotherapy and hormone therapy were evaluated in 25 separate examinations in total as follows: complete response (CR), when no bone metastasis was visible; partial response (PR), when a decrease in the lesion area was detected; stable disease (SD), when no or slight change was observed; and progressive disease (PD), when new or enlarged lesion areas were observed. Results: The accuracies of examination by Readers 1, 2, and 3 respectively were 76%, 80% and 76% for BS, 52%, 48%, and 40% for CT, and 64%, 52% and 60% for BS and CT combined with Readers 2 and 3 observing significant differences between CT and BS results. The rates of interobserver agreement between Readers 1 and 2, between Readers 1 and 3, and between Reader 2 and 3 respectively, were 84%, 80% and 88% (κ = 0.648, 0.561 and 0.766) for BS, 52%, 56%, and 60% (κ = 0.180, 0.278 and 0.282) for CT, and 52%, 60%, and 56% (κ = 0.215, 0.282 and 0.232) for CT and BS combined. Conclusion: BS is effective for assessing the response of bone metastasis to therapy in patients during zoledronic acid treatment. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/458 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/458/1/FksmJMedSci_61_p23.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2013-15 |
| PubMed番号: | 25946906 |
| 関連ページ: | http://doi.org/10.5387/fms.2013-15 |
| 権利情報: | © 2015 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.61 (2015)
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