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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.61 (2015) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/457
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| Title: | Anti-tumor immune responses induced by radiotherapy: a review |
| Authors: | Yoshimoto, Yuya
Kono, Koji
Suzuki, Yoshiyuki |
| Affiliation: | 先端がん免疫治療学講座
器官制御外科学講座
放射線腫瘍学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 61 |
| Issue: | 1 |
| Start page: | 13 |
| End page: | 22 |
| Issue Date: | 2015 |
| Abstract: | An anti-tumor immune response is one of the most important factors that can determine treatment response and prognosis of cancer patients. Recent studies have demonstrated that radiotherapy can activate tumor-specific immune responses and that these responses contribute to the therapeutic efficacy. However, the exact mechanisms underlying the radiation-induced immune responses remain unclear. Better understanding of the mechanisms could facilitate the application of immune-activating radiotherapy and provide new treatment strategies. We previously demonstrated that tumor-specific T cell responses could be induced in esophageal cancer patients during and after chemoradiotherapy. Furthermore, in a mouse model, immune responses played an important role in determining the local and systemic therapeutic efficacy of radiotherapy that could be augmented by the immune checkpoint blockade. In this review, radiotherapy-induced immune responses, the mechanisms underlying the induction of those responses, and a practical application of the therapy are discussed. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/457 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/457/1/FksmJMedSci_61_p13.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2015-6 |
| PubMed ID: | 26135666 |
| Related Page: | http://doi.org/10.5387/fms.2015-6 |
| Rights: | © 2015 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.61 (2015)
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