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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.60 (2014) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/423
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| Title: | Correlations among heavy metals in blood and urine and their relations to depressive symptoms in Parkinson's disease patients |
| Authors: | Fukushima, Tetsuhito
Tan, Xiaodong
Luo, Yunwen
Wang, Puqing
Song, Jinhui
Kanda, Hideyuki
Hayakawa, Takehito
Kumagai, Tomohiro
Kakamu, Takeyasu
Tsuji, Masayoshi
Hidaka, Tomoo
Mori, Yayoi |
| Affiliation: | 衛生学・予防医学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 60 |
| Issue: | 2 |
| Start page: | 108 |
| End page: | 115 |
| Issue Date: | 2014 |
| Abstract: | Objectives: From our previous results, manganese (Mn) and iron (Fe) in the blood of Parkinson's disease (PD) patients without depression were higher than those of both the PD patients with depression and controls, the hypothesis that "two types of PD exist-PD without depression and affected by Mn and Fe, and PD with depression and unaffected by Mn or Fe" was induced. To investigate the hypothesis, correlations among blood and urine metals were compared in the subjects. Methods: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from an outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals. Results: In the controls, Mn, Fe and zinc (Zn) levels in blood strongly correlated with each other. The correlation coefficient between Mn and Zn in blood was significant in the PD patients with depression and the controls, but not in the PD patients without depression. Correlations of Fe between blood and urine in the PD patients without depression were significant, but not in the PD patients with depression and the controls. Conclusions: A common route of simultaneous intake of Mn, Fe and Zn could exist in our subjects, however in PD patients without depression, a large intake of Mn may have been from another route. Some results of the PD patients without depression were different from those of the PD patients with depression and the controls. Thus, two types of PD may exist. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/423 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/423/1/FksmJMedSci_60_p108.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2014-8 |
| PubMed ID: | 25283978 |
| Related Page: | http://doi.org/10.5387/fms.2014-8 |
| Rights: | © 2014 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.60 (2014)
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