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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.60 (2014) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/423
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| タイトル: | Correlations among heavy metals in blood and urine and their relations to depressive symptoms in Parkinson's disease patients |
| 著者: | Fukushima, Tetsuhito
Tan, Xiaodong
Luo, Yunwen
Wang, Puqing
Song, Jinhui
Kanda, Hideyuki
Hayakawa, Takehito
Kumagai, Tomohiro
Kakamu, Takeyasu
Tsuji, Masayoshi
Hidaka, Tomoo
Mori, Yayoi |
| 学内所属: | 衛生学・予防医学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 60 |
| 号: | 2 |
| 開始ページ: | 108 |
| 終了ページ: | 115 |
| 発行日: | 2014年 |
| 抄録: | Objectives: From our previous results, manganese (Mn) and iron (Fe) in the blood of Parkinson's disease (PD) patients without depression were higher than those of both the PD patients with depression and controls, the hypothesis that "two types of PD exist-PD without depression and affected by Mn and Fe, and PD with depression and unaffected by Mn or Fe" was induced. To investigate the hypothesis, correlations among blood and urine metals were compared in the subjects. Methods: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from an outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals. Results: In the controls, Mn, Fe and zinc (Zn) levels in blood strongly correlated with each other. The correlation coefficient between Mn and Zn in blood was significant in the PD patients with depression and the controls, but not in the PD patients without depression. Correlations of Fe between blood and urine in the PD patients without depression were significant, but not in the PD patients with depression and the controls. Conclusions: A common route of simultaneous intake of Mn, Fe and Zn could exist in our subjects, however in PD patients without depression, a large intake of Mn may have been from another route. Some results of the PD patients without depression were different from those of the PD patients with depression and the controls. Thus, two types of PD may exist. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/423 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/423/1/FksmJMedSci_60_p108.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2014-8 |
| PubMed番号: | 25283978 |
| 関連ページ: | http://doi.org/10.5387/fms.2014-8 |
| 権利情報: | © 2014 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.60 (2014)
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