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Vol.60 (2014) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/405

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Title: Oral rabeprazole administration on a procedure day suppresses bleeding after endoscopic submucosal dissection for gastric neoplasms
Authors: Hikichi, Takuto
Sato, Masaki
Watanabe, Ko
Nakamura, Jun
Takagi, Tadayuki
Suzuki, Rei
Sugimoto, Mitsuru
Waragai, Yuichi
Kikuchi, Hitomi
Konno, Naoki
Ohira, Hiromasa
Obara, Katsutoshi
Affiliation: 内視鏡診療部
消化器・リウマチ膠原病内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 60
Issue: 1
Start page: 68
End page: 74
Issue Date: 8-Aug-2014
Abstract: [Aim] The efficacy of pre-procedure oral proton pump inhibitor (PPI) administration for gastric endoscopic submucosal dissection (ESD) is unclear. This study evaluated oral PPI administration effectiveness on the day of ESD to prevent post-ESD bleeding. [Methods] This study examined 55 patients who underwent ESD for gastric neoplasm. Group A comprised 31 patients who took rabeprazole sodium (RPZ) 20 mg/day beginning 7-8 hr before ESD. Group B comprised 24 who took RPZ 20 mg/day beginning three days before ESD. Gastric pH (G-pH) was measured at one month before ESD (pre-ESD pH), immediately before ESD (ESD pH), and seven days after ESD (post-ESD pH). The post-ESD bleeding rate and changes in G-pH were recorded. [Results] No significant difference in post-ESD bleeding rates was found (Group A 3.2%, Group B 0%). ESD pH and post-ESD pH were significantly higher than pre-ESD pH in both groups (P<0.001). The ESD pH for Group A was higher than 6 (6.5±1.1), providing hemostasis for intragastric bleeding. [Conclusions] Oral RPZ administration on the day of gastric ESD can suppress post-ESD bleeding equivalently to administration three days before ESD.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/405
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/405/1/FksmJMedSci_60_p68.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.2013-17
PubMed ID: 25030714
Related Page: http://dx.doi.org/10.5387/fms.2013-17
Rights: © 2014 The Fukushima Society of Medical Science
Appears in Collections:Vol.60 (2014)

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FksmJMedSci_60_p68.pdf186.57 kBAdobe PDFDownload

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