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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.60 (2014) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/401
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| タイトル: | Therapeutic efficacy of pregabalin in patients with leg symptoms due to lumbar spinal stenosis |
| 著者: | Takahashi, Naoto
Arai, Itaru
Kayama, Satoru
Ichiji, Kenji
Fukuda, Hironari
Kaga, Takahiro
Konno, Shin-Ichi |
| 学内所属: | 整形外科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 60 |
| 号: | 1 |
| 開始ページ: | 35 |
| 終了ページ: | 42 |
| 発行日: | 2014年8月8日 |
| 抄録: | The purpose of this study was to evaluate the therapeutic efficacy of pregabalin in patients with leg symptoms due to lumbar spinal stenosis. Study subjects were classified into two groups according to their pharmacotherapy: the pregabalin group, treated with nonsteroidal anti-inflammatory drug and pregabalin combination therapy, and the control group, treated with nonsteroidal anti-inflammatory drug monotherapy. The two groups were compared in terms of the duration of pain after the onset of leg symptoms and the type of neurogenic intermittent claudication, whether radicular-, caudal-, or mixed-type. Numerical rating scale and Roland-Morris Disability Questionnaire scores were evaluated before and 3 months after treatment. After 3 months of treatment, there were significant differences in the numerical rating scale for radicular- and mixed-types, but not for caudal-type, between the two groups in the subjects with leg symptoms for greater than 3 months. There were significant differences between the two groups in Roland-Morris Disability Questionnaire scores for mixed-type, but not for radicular- and caudal-types, in the subjects with leg symptoms for less than 3 months and for radicular- and mixed-types, but not for caudal-type, in the subjects with leg symptoms for greater than 3 months. Nonsteroidal anti-inflammatory drug and pregabalin combination therapy may be more effective than nonsteroidal anti-inflammatory drug monotherapy for the relief of leg symptoms due to lumbar spinal stenosis, preventing aggravation of subjective symptoms and improving quality of life for patients with radicular- and mixed-types in subjects with leg symptoms for greater than 3 months, although it may be necessary to consider alternative therapy for patients with caudal-type. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/401 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/401/1/FksmJMedSci_60_p35.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2013-22 |
| PubMed番号: | 25030722 |
| 関連ページ: | http://dx.doi.org/10.5387/fms.2013-22 |
| 権利情報: | © 2014 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.60 (2014)
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