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Vol.60 (2014) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/401

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Title: Therapeutic efficacy of pregabalin in patients with leg symptoms due to lumbar spinal stenosis
Authors: Takahashi, Naoto
Arai, Itaru
Kayama, Satoru
Ichiji, Kenji
Fukuda, Hironari
Kaga, Takahiro
Konno, Shin-Ichi
Affiliation: 整形外科学講座
Source title: Fukushima Journal of Medical Science
Volume: 60
Issue: 1
Start page: 35
End page: 42
Issue Date: 8-Aug-2014
Abstract: The purpose of this study was to evaluate the therapeutic efficacy of pregabalin in patients with leg symptoms due to lumbar spinal stenosis. Study subjects were classified into two groups according to their pharmacotherapy: the pregabalin group, treated with nonsteroidal anti-inflammatory drug and pregabalin combination therapy, and the control group, treated with nonsteroidal anti-inflammatory drug monotherapy. The two groups were compared in terms of the duration of pain after the onset of leg symptoms and the type of neurogenic intermittent claudication, whether radicular-, caudal-, or mixed-type. Numerical rating scale and Roland-Morris Disability Questionnaire scores were evaluated before and 3 months after treatment. After 3 months of treatment, there were significant differences in the numerical rating scale for radicular- and mixed-types, but not for caudal-type, between the two groups in the subjects with leg symptoms for greater than 3 months. There were significant differences between the two groups in Roland-Morris Disability Questionnaire scores for mixed-type, but not for radicular- and caudal-types, in the subjects with leg symptoms for less than 3 months and for radicular- and mixed-types, but not for caudal-type, in the subjects with leg symptoms for greater than 3 months. Nonsteroidal anti-inflammatory drug and pregabalin combination therapy may be more effective than nonsteroidal anti-inflammatory drug monotherapy for the relief of leg symptoms due to lumbar spinal stenosis, preventing aggravation of subjective symptoms and improving quality of life for patients with radicular- and mixed-types in subjects with leg symptoms for greater than 3 months, although it may be necessary to consider alternative therapy for patients with caudal-type.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/401
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/401/1/FksmJMedSci_60_p35.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.2013-22
PubMed ID: 25030722
Related Page: http://dx.doi.org/10.5387/fms.2013-22
Rights: © 2014 The Fukushima Society of Medical Science
Appears in Collections:Vol.60 (2014)

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FksmJMedSci_60_p35.pdf210.7 kBAdobe PDFDownload

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