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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.60 (2014) >
このアイテムの引用には次の識別子を使用してください:
http://ir.fmu.ac.jp/dspace/handle/123456789/398
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| タイトル: | Neutrophil elastase inhibitor suppresses IL-17 based inflammation of murine experimental colitis |
| 著者: | Shioya, Yasuo
Katakura, Kyoko
Ohira, Hiromasa |
| 学内所属: | 消化器・リウマチ膠原病内科学講座 |
| 誌名/書名: | Fukushima Journal of Medical Science |
| 巻: | 60 |
| 号: | 1 |
| 開始ページ: | 14 |
| 終了ページ: | 21 |
| 発行日: | 2014年8月8日 |
| 抄録: | [Background] Neutrophil elastase (NE) is a proteinase in granulocytes and plays an important role in the pathogenesis of inflammatory disorders. It has been reported that NE activity is elevated in both colonic mucosa and blood in inflammatory bowel disease (IBD) patients, and that it can act as an aggravating factor in IBD. To develop novel therapies for IBD, we examined the effects of an NE inhibitor, Elaspor®, on murine experimental colitis. [Methods] Acute colitis was induced in BALB/c mice by administration of dextran sulfate sodium (DSS) in drinking water for 7 days. NE inhibitor was administered subcutaneously to mice prior to and during the induction of colitis. Disease activity index (DAI), colonic myeloperoxidase (MPO) activity, luminal NE activity, and mRNA expression in the colon were then investigated. [Results] Subcutaneous administration of NE inhibitor ameliorated the severity of DSS-induced colitis. NE activity was elevated in inflamed colon, and was reduced by NE inhibitor administration. mRNA expression levels of IL-17, a Th17-based inflammatory factor, was also decreased in the colon of NE inhibitor-administered mice. [Conclusion] These results suggest that NE inhibitor ameliorated colonic inflammation by decreasing both the activity of NE and the effects of cytokine balance. Clinically, NE inhibitor improves injuries associated with systemic inflammatory response syndrome. Similarly, clinical use of this inhibitor would further clarify its usefulness in clinical colonic inflammation. |
| 出版者: | The Fukushima Society of Medical Science |
| 出版者（異表記）: | 福島医学会 |
| 本文の言語: | eng |
| このページのURI: | http://ir.fmu.ac.jp/dspace/handle/123456789/398 |
| 本文URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/398/1/FksmJMedSci_60_p14.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.2013-2 |
| PubMed番号: | 24670675 |
| 関連ページ: | http://dx.doi.org/10.5387/fms.2013-2 |
| 権利情報: | © 2014 The Fukushima Society of Medical Science |
| 出現コレクション: | Vol.60 (2014)
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