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Vol.59 (2013)  >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/376

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Title: Efficacy of cyclosporine a for steroid-resistant severe henoch-schönlein purpura nephritis
Authors: Ohara, Shinichiro
Kawasaki, Yukihiko
Miyazaki, Kyohei
Ono, Atsushi
Suzuki, Yuichi
Suyama, Kazuhide
Hosoya, Mitsuaki
Affiliation: 小児科学講座
Source title: Fukushima Journal of Medical Science
Volume: 59
Issue: 2
Start page: 102
End page: 107
Issue Date: 2013
Abstract: Aggressive treatment is necessary for continuous high-range proteinuria in cases of pediatric Henoch-Schönlein purpura nephritis (HSPN) as the long-term prognosis is sometimes poor. Cyclosporine (CyA) has immunosuppressive effects as well as a very selective inhibitory effect on T-helper cell function. Here we report two 7-year-old boys with steroid-resistant HSPN treated with CyA. After diagnosis of HSPN, we treated both patients with methylprednisolone and urokinase pulse therapy (MUT) combined with multiple drugs; however, high-range proteinuria persisted and CyA was added to the treatment regimen. The proteinuria subsequently decreased gradually and pathological findings at the second renal biopsy were improved. Furthermore, neither patient showed any adverse effects, such as hypertension, encephalopathy, or chronic nephrotoxicity, to the CyA treatment.In conclusion, these results suggest that CyA may be a safe and effective treatment for steroid-resistant severe HSPN.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/376
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/376/1/FksmJMedSci_59_p102.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.59.102
PubMed ID: 24500387
Related Page: http://dx.doi.org/10.5387/fms.59.102
Rights: © 2013 The Fukushima Society of Medical Science
Appears in Collections:Vol.59 (2013)

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FksmJMedSci_59_p102.pdf738.59 kBAdobe PDFDownload

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