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Vol.59 (2013)  >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/359

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Title: Recent progress and new perspectives in lymphoma glycobiology
Other Titles: Biological significance of glycosylation in human malignant lymphoma
Authors: Suzuki, Osamu
Abe, Masafumi
Affiliation: 病理病態診断学講座
Source title: Fukushima Journal of Medical Science
Volume: 59
Issue: 1
Start page: 1
End page: 14
Issue Date: 2013
Abstract: Glycosylation has recently become one of the most significant subjects in tumor biology, and cell surface glycosylation is closely associated with various biological phenomena in tumor cells. However, the biological significance of cell surface glycosylation and sialic acid linked to glycans in human malignant lymphoma is not well elucidated. We have determined that 1) sialylation or loss of N-glycosylation is closely associated with a worse prognosis in human diffuse large B-cell lymphoma (DLBCL), and 2) glycosylation or sialic acid on the surface of lymphoma cells plays significant roles in cell adhesion or invasion to the extracellular matrix, cell growth, apoptosis and cell death. In the present review, the biological functions of glycosylation or sialic acid in human malignant lymphoma are discussed.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/359
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/359/1/FksmJMedSci_59_p1.pdf
ISSN: 0016-2590
DOI: 10.5387/fms.59.1
PubMed ID: 23842509
Related Page: http://dx.doi.org/10.5387/fms.59.1
Rights: © 2013 The Fukushima Society of Medical Science
Appears in Collections:Vol.59 (2013)

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