|
福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
福島医学会 = The Fukushima Society of Medical Science >
Fukushima Journal of Medical Science >
Vol.59 (2013) >
Please use this identifier to cite or link to this item:
http://ir.fmu.ac.jp/dspace/handle/123456789/359
|
| Title: | Recent progress and new perspectives in lymphoma glycobiology |
| Other Titles: | Biological significance of glycosylation in human malignant lymphoma |
| Authors: | Suzuki, Osamu
Abe, Masafumi |
| Affiliation: | 病理病態診断学講座 |
| Source title: | Fukushima Journal of Medical Science |
| Volume: | 59 |
| Issue: | 1 |
| Start page: | 1 |
| End page: | 14 |
| Issue Date: | 2013 |
| Abstract: | Glycosylation has recently become one of the most significant subjects in tumor biology, and cell surface glycosylation is closely associated with various biological phenomena in tumor cells. However, the biological significance of cell surface glycosylation and sialic acid linked to glycans in human malignant lymphoma is not well elucidated. We have determined that 1) sialylation or loss of N-glycosylation is closely associated with a worse prognosis in human diffuse large B-cell lymphoma (DLBCL), and 2) glycosylation or sialic acid on the surface of lymphoma cells plays significant roles in cell adhesion or invasion to the extracellular matrix, cell growth, apoptosis and cell death. In the present review, the biological functions of glycosylation or sialic acid in human malignant lymphoma are discussed. |
| Publisher: | The Fukushima Society of Medical Science |
| Publisher (Alternative foam): | 福島医学会 |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/359 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/359/1/FksmJMedSci_59_p1.pdf |
| ISSN: | 0016-2590
2185-4610 |
| DOI: | 10.5387/fms.59.1 |
| PubMed ID: | 23842509 |
| Related Page: | http://dx.doi.org/10.5387/fms.59.1 |
| Rights: | © 2013 The Fukushima Society of Medical Science |
| Appears in Collections: | Vol.59 (2013)
|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
|
