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福島県立医科大学学術成果リポジトリ = Fukushima Medical University Repository >
A 医学部 = School of Medicine >
a10 学術雑誌論文等 = Journal Article >
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http://ir.fmu.ac.jp/dspace/handle/123456789/357
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| Title: | Clinical features of liver dysfunction in collagen diseases |
| Other Titles: | Liver dysfunction in collagen disease |
| Authors: | Takahashi, Atsushi
Abe, Kazumichi
Yokokawa, Junko
Iwadate, Haruyo
Kobayashi, Hiroko
Watanabe, Hiroshi
Irisawa, Atsushi
Ohira, Hiromasa |
| Affiliation: | 消化器・リウマチ膠原病内科学講座 |
| Source title: | Hepatology Research |
| Volume: | 40 |
| Issue: | 11 |
| Start page: | 1092 |
| End page: | 1097 |
| Issue Date: | Nov-2010 |
| Abstract: | Aim: Liver dysfunction is not rare in patients with collagen disease. We sought to elucidate the clinical features of liver dysfunction in the presence of collagen disease. Methods: We analyzed the frequency and causes of liver dysfunction in 607 patients (rheumatoid arthritis [RA], n = 220; systemic lupus erythematosus [SLE], n = 164; systemic sclerosis [SSc], n = 47; Sjögren's syndrome [SjS], n = 44; Behçet's disease, n = 43; polymyositis/dermatomyositis [PM/DM], n = 27; vasculitis syndrome, n = 25; mixed connective tissue disease [MCTD], n = 21; and adult-onset Still's disease [AOSD], n = 16). Results: Liver dysfunction was observed in 238 (39.2%) of 607 patients showing collagen disease. Patients with AOSD (81.3%), PM/DM (51.9%) and vasculitis syndrome (48.0%) frequently displayed liver dysfunction. Liver dysfunction in collagen diseases results from many causes; drug-induced liver injury (26.1%), fatty liver (7.6%), viral hepatitis (1.3%), autoimmune hepatitis (4.2%), primary biliary cirrhosis (15.9%) and the collagen disease itself (15.5%). Conversely, primary biliary cirrhosis was a leading cause in SSc (76.1%) and SjS (70.0%). Liver dysfunction in collagen disease tended to be mild. In addition, alanine aminotransferase levels correlated positively with ferritin levels in AOSD (R = 0.708, P < 0.05). Moreover, alkaline phosphatase levels correlated positively with C reactive protein levels in vasculitis syndrome (R = 0.833, P < 0.05). Conclusion: Liver dysfunction in the presence of collagen disease has various causes, and dysfunction associated with collagen disease reflects the activity of the collagen disease itself. |
| Publisher: | Wiley-Blackwell |
| language: | eng |
| URI: | http://ir.fmu.ac.jp/dspace/handle/123456789/357 |
| Full text URL: | http://ir.fmu.ac.jp/dspace/bitstream/123456789/357/1/HepatolRes_40_p1092.pdf |
| ISSN: | 1386-6346 |
| DOI: | 10.1111/j.1872-034X.2010.00707.x |
| PubMed ID: | 20880057 |
| Other version: | http://dx.doi.org/10.1111/j.1872-034X.2010.00707.x |
| Rights: | Author posting. © The Japan Society of Hepatology 2010. This is the author’s version of the work. It is posted here by permission of Hepatology Research. 40(11):1092-1097. http://dx.doi.org/10.1111/j.1872-034X.2010.00707.x |
| Appears in Collections: | a10 学術雑誌論文等 = Journal Article
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