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Title: Clinical features of liver dysfunction in collagen diseases
Other Titles: Liver dysfunction in collagen disease
Authors: Takahashi, Atsushi
Abe, Kazumichi
Yokokawa, Junko
Iwadate, Haruyo
Kobayashi, Hiroko
Watanabe, Hiroshi
Irisawa, Atsushi
Ohira, Hiromasa
Affiliation: 消化器・リウマチ膠原病内科学講座
Source title: Hepatology Research
Volume: 40
Issue: 11
Start page: 1092
End page: 1097
Issue Date: Nov-2010
Abstract: Aim:  Liver dysfunction is not rare in patients with collagen disease. We sought to elucidate the clinical features of liver dysfunction in the presence of collagen disease. Methods:  We analyzed the frequency and causes of liver dysfunction in 607 patients (rheumatoid arthritis [RA], n = 220; systemic lupus erythematosus [SLE], n = 164; systemic sclerosis [SSc], n = 47; Sjögren's syndrome [SjS], n = 44; Behçet's disease, n = 43; polymyositis/dermatomyositis [PM/DM], n = 27; vasculitis syndrome, n = 25; mixed connective tissue disease [MCTD], n = 21; and adult-onset Still's disease [AOSD], n = 16). Results:  Liver dysfunction was observed in 238 (39.2%) of 607 patients showing collagen disease. Patients with AOSD (81.3%), PM/DM (51.9%) and vasculitis syndrome (48.0%) frequently displayed liver dysfunction. Liver dysfunction in collagen diseases results from many causes; drug-induced liver injury (26.1%), fatty liver (7.6%), viral hepatitis (1.3%), autoimmune hepatitis (4.2%), primary biliary cirrhosis (15.9%) and the collagen disease itself (15.5%). Conversely, primary biliary cirrhosis was a leading cause in SSc (76.1%) and SjS (70.0%). Liver dysfunction in collagen disease tended to be mild. In addition, alanine aminotransferase levels correlated positively with ferritin levels in AOSD (R = 0.708, P < 0.05). Moreover, alkaline phosphatase levels correlated positively with C reactive protein levels in vasculitis syndrome (R = 0.833, P < 0.05). Conclusion:  Liver dysfunction in the presence of collagen disease has various causes, and dysfunction associated with collagen disease reflects the activity of the collagen disease itself.
Publisher: Wiley-Blackwell
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/357
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/357/1/HepatolRes_40_p1092.pdf
ISSN: 1386-6346
DOI: 10.1111/j.1872-034X.2010.00707.x
PubMed ID: 20880057
Other version: http://dx.doi.org/10.1111/j.1872-034X.2010.00707.x
Rights: Author posting. © The Japan Society of Hepatology 2010. This is the author’s version of the work. It is posted here by permission of Hepatology Research. 40(11):1092-1097. http://dx.doi.org/10.1111/j.1872-034X.2010.00707.x
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