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Vol.58 (2012) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/338

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Title: Autoantibodies by line immunoassay in patients with primary biliary cirrhosis
Other Titles: Autoantibodies in PBC
Authors: Saito, Hironobu
Takahashi, Atsushi
Abe, Kazumichi
Okai, Ken
Katsushima, Fumiko
Monoe, Kyoko
Kanno, Yukiko
Ohira, Hiromasa
Affiliation: 消化器・リウマチ膠原病内科学講座
Source title: Fukushima Journal of Medical Science
Volume: 58
Issue: 2
Start page: 107
End page: 116
Issue Date: 2012
Abstract: Objectives: We attempted to measure multiple autoantibodies simultaneously using line immunoassay (LIA) in patients with primary biliary cirrhosis (PBC) with or without anti-mitochondrial antibody (AMA) and patients with PBC-autoimmune hepatitis (AIH) overlap, and we examined the clinical significance of measuring these autoantibodies. Methods: The study population consisted of 80 patients with PBC (including 12 AMA-negative patients), 16 patients with PBC-AIH overlap and 40 patients with AIH as controls. Nine antibodies (AMA-M2, M2-3E, Sp100, PML, gp210, Ro-52, LKM-1, LC-1 and SLA/LP) were detected by LIA, and AMA-M2 and anti-centromere antibody (ACA) were detected by ELISA. We examined the relationship between these autoantibodies and clinical findings. Results: The positive prevalence of each autoantibody and ACA in the PBC group, as determined by LIA, was as follows: 13.8% for anti-Sp100, 8.7% for anti-PML, 40% for anti-gp210 and 27.5% for anti-Ro-52 antibodies and 32.5% for ACA. In the PBC-AIH overlap group, the prevalence of anti-gp210 antibody (68.7%) and that of anti-Ro-52 antibody (81.2%) were significantly higher than those in the PBC and AIH groups. Only a few patients were positive for 2 or more autoantibodies. Nine patients were determined to be negative for all autoantibodies by LIA, of whom 7 were positive for ACA. Patients positive for anti-gp210 antibody included more patients classified as stage 4 on histology than did the negative group. Those positive for ACA included more patents with varices than did the negative group. Conclusion: LIA can measure multiple autoantibodies simultaneously and thus is considered useful in diagnosing PBC and PBC-AIH overlap. In addition, ACA is a useful marker for identifying AMA-negative PBC.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/338
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/338/1/FksmJMedSci_58_p107.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.58.107
PubMed ID: 23237866
Other version: http://dx.doi.org/10.5387/fms.58.107
Rights: © 2012 The Fukushima Society of Medical Science
Appears in Collections:Vol.58 (2012)

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FksmJMedSci_58_p107.pdf433.07 kBAdobe PDFDownload

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