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Vol.58 (2012) >

Please use this identifier to cite or link to this item: http://ir.fmu.ac.jp/dspace/handle/123456789/322

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Title: Clinical evaluation of dendritic cells vaccination for advanced cancer patients at fukushima medical university
Authors: Nakamura, Izumi
Kanazawa, Masashi
Sato, Yu
Irisawa, Atsushi
Takagi, Tadayuki
Ogata, Takashi
Kashimura, Shogo
Kenjo, Akira
Suzuki, Hiroyuki
Shibata, Masahiko
Shimura, Tatsuo
Ohira, Hiromasa
Goto, Mitsukazu
Takenoshita, Seiichi
Ohto, Hitoshi
Affiliation: 器官制御外科学講座
会津医療センター準備室
消化器・リウマチ膠原病内科学講座
臓器再生外科学講座
腫瘍生体治療学講座
輸血・移植免疫学講座
Source title: Fukushima Journal of Medical Science
Volume: 58
Issue: 1
Start page: 40
End page: 48
Issue Date: 2012
Abstract: Dendritic cells (DCs) are powerful antigen-presenting cells (APCs) that have attracted attention in recent years from the viewpoint of DC vaccine therapy against cancer. However, the existence of a strongly immunosuppressed state in cancer-bearing individuals inhibits DC maturation, which is one of the problems facing anti-cancer DC vaccine therapy. Isolated DCs loaded with tumor antigen ex vivo and administered as a cellular vaccine have been found to induce protective and therapeutic anti-tumor immunity in experimental animals. In clinical trials of DC vaccination for cancer patients, induction of anti-tumor immune responses and tumor regression has been observed. In this study, eighty-one advanced cancer patients unsuccessfully treated by established treatment in individual cases were selected between January 2002 and May 2007 at Fukushima Medical University. The usefulness of DC therapy was investigated by intradermal injection of peptide pulsed DCs for an overall objective response rate of 28.0%. Furthermore, direct injection of immature DCs into tumor extracted an overall objective response rate of 35.7%, and especially 40.0% for advanced pancreatic cancer by using endoscopic ultrasound-guided fine-needle injection technique as a novel approach. These results indicate that DC-based vaccination could be a promising treatment modality for various cancers, however multiple hurdles must be cleared before the development of an affordable DC-based vaccination can be used worldwide.
Publisher: The Fukushima Society of Medical Science
Publisher (Alternative foam): 福島医学会
language: eng
URI: http://ir.fmu.ac.jp/dspace/handle/123456789/322
Full text URL: http://ir.fmu.ac.jp/dspace/bitstream/123456789/322/1/FksmJMedSci_58_p40.pdf
ISSN: 0016-2590
2185-4610
DOI: 10.5387/fms.58.40
PubMed ID: 22790891
Other version: http://dx.doi.org/10.5387/fms.58.40
Rights: © 2012 The Fukushima Society of Medical Science
Appears in Collections:Vol.58 (2012)

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FksmJMedSci_58_p40.pdf374.63 kBAdobe PDFDownload

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